Trial reportThe Journal of pediatrics2008
Poor immune responses to a birth dose of diphtheria, tetanus, and acellular pertussis vaccine.
Trial report in The Journal of pediatrics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 130 citations in OpenAlex.
- Efficacy and safety of pertussis vaccination for pregnant women - a systematic review of randomised controlled trials and observational studies.BMC pregnancy and childbirth · 2017Pooled it
- Non-specific immunological effects of selected routine childhood immunisations: systematic review.BMJ (Clinical research ed.) · 2016Pooled it
- Immunogenicity and Safety of Monovalent Acellular Pertussis Vaccine at Birth: A Randomized Clinical Trial.JAMA pediatrics · 2018Trial
- Knowledge, attitudes, beliefs, and behaviors of pregnant women approached to participate in a Tdap maternal immunization randomized, controlled trial.Human vaccines & immunotherapeutics · 2016Trial
- Innovations in Career Development Through Mentoring in the VTEU/IDCRC Programs.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025Article
- Predictors of maternal pertussis vaccination acceptance among pregnant women in Norway.Human vaccines & immunotherapeutics · 2024Article
- Improving Tdap maternal immunization rate in Saudi Arabia.Human vaccines & immunotherapeutics · 2023Article
- Are the first 1,000 days of life a neglected vital period to prevent the impact on maternal and infant morbimortality of infectious diseases in Latin America? Proceedings of a workshop of experts from the Latin American Pediatric Infectious Diseases Society, SLIPE.Frontiers in pediatrics · 2023Review
- Early-life microbiota-immune homeostasis.Frontiers in immunology · 2023Review
- The Path to New Pediatric Vaccines against Pertussis.Vaccines · 2021Review
- Harnessing early life immunity to develop a pediatric HIV vaccine that can protect through adolescence.PLoS pathogens · 2020Article
- Neonatal vaccine effectiveness and the role of adjuvants.Expert review of clinical immunology · 2019Review
- Factors That Influence the Immune Response to Vaccination.Clinical microbiology reviews · 2019Review
- Neonatal Immunization: Rationale, Current State, and Future Prospects.Frontiers in immunology · 2018Review
- The Impact of IgG transplacental transfer on early life immunity.ImmunoHorizons · 2018Article
- Vaccine responses in newborns.Seminars in immunopathology · 2017Review
- Immunization During Pregnancy: Impact on the Infant.Paediatric drugs · 2017Review
- Pertussis vaccination in pregnancy.Human vaccines & immunotherapeutics · 2016Review
- Pertussis: Microbiology, Disease, Treatment, and Prevention.Clinical microbiology reviews · 2016Review
- Influenza in Infants Born to Women Vaccinated During Pregnancy.Pediatrics · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesTo evaluate the safety and immunogenicity of an additional birth dose of diphtheria, tetanus, and acellular pertussis vaccine (DTaP). STUDY
designFifty infants between 2 to 14 days of age were randomly assigned to receive either DTaP and hepatitis B vaccines (experimental) or hepatitis B alone (control) at birth. At 2, 4, 6, and 17 months of age, DTaP and routine vaccines were administered to both groups. Safety data were collected after each dose, and sera were obtained at birth, 6, 7, 17, and 18 months. Immune responses to pertussis toxin, filamentous hemagglutinin, pertactin, and fimbriae were measured by enzyme-linked immunosorbent assay; responses to other vaccines were assessed.
resultsNo differences were seen between the 2 groups in either local or systemic reactions; all vaccines were well tolerated. Compared with the control group, infants in the experimental group demonstrated significantly lower geometric mean antibody concentrations for pertussis toxin and pertactin 6, 7, and 18 months, for fimbrae at 6, 7, 17, and 18 months, and for FHA at 18 months, and lower geometric mean antibody concentrations for diphtheria at 7 months. Immune responses to all other vaccine antigens were comparable.
conclusionAdministration of an additional dose of DTaP at birth was safe but was associated with a significantly lower response to diphtheria and 3 of 4 pertussis antigens compared with controls.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.