ArticleBMC genomics2008
Highly plastic genome of Microcystis aeruginosa PCC 7806, a ubiquitous toxic freshwater cyanobacterium.
Article in BMC genomics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
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Who cites it
85 citing papers in PubMed.
- Concentration-dependent stimulatory and inhibitory effects of β-cyclocitral, longifolene, and β-ionone on Microcystis aeruginosa.World journal of microbiology & biotechnology · 2026Article
- Phylogenomic diversity and chromatic acclimation in phycoerythrin-containingMicrobial genomics · 2026Article
- Environmental disturbances and cyanobacterial traits shape prokaryotic dynamics in a eutrophic Mediterranean coastal lagoon.Environmental microbiome · 2026Article
- Metabolite diversity of Microcystis strains shows tight correspondence to genotype and may contribute to ecotype specificities.Communications biology · 2026Article
- A metagenomic snapshot of metabolic potentials in wintertime eutrophic sediments of Lake Taihu inferred from metagenome-assembled genomes.Frontiers in microbiology · 2026Article
- Nitrogen Substrate Impacts Microcystis aeruginosa Exometabolome Composition.Environmental microbiology reports · 2025Article
- Stress genomics of the toxigenic cyanobacteria: environmental and biotechnological perspectives.World journal of microbiology & biotechnology · 2025Review
- Comparative genomic analysis of a novel heat-tolerant and euryhaline strain of unicellular marine cyanobacterium Cyanobacterium sp. DS4 from a high-temperature lagoon.BMC microbiology · 2025Article
- Species evolution: cryptic species and phenotypic noise with a particular focus on fungal systematics.Frontiers in cellular and infection microbiology · 2025Review
- Article
- Mobilome impacts on physiology in the widely used non-toxic mutant Microcystis aeruginosa PCC 7806 ΔmcyB and toxic wildtype.BMC genomics · 2024Article
- A novel hierarchical network-based approach to unveil the complexity of functional microbial genome.BMC genomics · 2024Article
- Profiling the interplay and coevolution ofMicrobiology spectrum · 2024Article
- Resilience and Mitigation Strategies of Cyanobacteria under Ultraviolet Radiation Stress.International journal of molecular sciences · 2023Review
- Cyanotoxins and Other Bioactive Compounds from the Pasteur Cultures of Cyanobacteria (PCC).Toxins · 2023Review
- The Special and General Mechanism of Cyanobacterial Harmful Algal Blooms.Microorganisms · 2023Review
- Article
- Temporal and functional interrelationships between bacterioplankton communities and the development of a toxigenic Microcystis bloom in a lowland European reservoir.Scientific reports · 2022Article
- A New Gene Family Diagnostic for Intracellular Biomineralization of Amorphous Ca Carbonates by Cyanobacteria.Genome biology and evolution · 2022Article
- Toxic/Bioactive Peptide Synthesis Genes Rearranged by Insertion Sequence Elements Among the Bloom-Forming CyanobacteriaFrontiers in microbiology · 2022Article
25 more citing papers are in PubMed but not listed here.
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Authors and funding
20 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe colonial cyanobacterium Microcystis proliferates in a wide range of freshwater ecosystems and is exposed to changing environmental factors during its life cycle. Microcystis blooms are often toxic, potentially fatal to animals and humans, and may cause environmental problems. There has been little investigation of the genomics of these cyanobacteria.
resultsDeciphering the 5,172,804 bp sequence of Microcystis aeruginosa PCC 7806 has revealed the high plasticity of its genome: 11.7% DNA repeats containing more than 1,000 bases, 6.8% putative transposases and 21 putative restriction enzymes. Compared to the genomes of other cyanobacterial lineages, strain PCC 7806 contains a large number of atypical genes that may have been acquired by lateral transfers. Metabolic pathways, such as fermentation and a methionine salvage pathway, have been identified, as have genes for programmed cell death that may be related to the rapid disappearance of Microcystis blooms in nature. Analysis of the PCC 7806 genome also reveals striking novel biosynthetic features that might help to elucidate the ecological impact of secondary metabolites and lead to the discovery of novel metabolites for new biotechnological applications. M. aeruginosa and other large cyanobacterial genomes exhibit a rapid loss of synteny in contrast to other microbial genomes.
conclusionMicrocystis aeruginosa PCC 7806 appears to have adopted an evolutionary strategy relying on unusual genome plasticity to adapt to eutrophic freshwater ecosystems, a property shared by another strain of M. aeruginosa (NIES-843). Comparisons of the genomes of PCC 7806 and other cyanobacterial strains indicate that a similar strategy may have also been used by the marine strain Crocosphaera watsonii WH8501 to adapt to other ecological niches, such as oligotrophic open oceans.
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