ArticleBMC genetics2008
Selection, diversity and evolutionary patterns of the MHC class II DAB in free-ranging Neotropical marsupials.
Article in BMC genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 34 citations in OpenAlex.
- Trans-specific polymorphism and the convergent evolution of supertypes in major histocompatibility complex class II genes in darters (Ecology and evolution · 2022Article
- Article
- Spatial pattern of genetic diversity and selection in the MHC class II DRB of three Neotropical bat species.BMC evolutionary biology · 2016Article
- Evidence for selection maintaining MHC diversity in a rodent species despite strong density fluctuations.Immunogenetics · 2016Article
- Contrasting evolutionary histories of MHC class I and class II loci in grouse--effects of selection and gene conversion.Heredity · 2016Article
- Trans-species polymorphism in humans and the great apes is generally maintained by balancing selection that modulates the host immune response.Human genomics · 2015Review
- Article
- Parasite-mediated selection of major histocompatibility complex variability in wild brandt's voles (Lasiopodomys brandtii) from Inner Mongolia, China.BMC evolutionary biology · 2013Article
- Characterisation of four major histocompatibility complex class II genes of the koala (Phascolarctos cinereus).Immunogenetics · 2013Article
- The functional importance of sequence versus expression variability of MHC alleles in parasite resistance.Genetica · 2012Article
- Low MHC class II diversity in the Tasmanian devil (Sarcophilus harrisii).Immunogenetics · 2012Article
- The tammar wallaby major histocompatibility complex shows evidence of past genomic instability.BMC genomics · 2011Article
- MHC class II DRB diversity, selection pattern and population structure in a neotropical bat species, Noctilio albiventris.Heredity · 2011Article
- Article
- Immigration rates in fragmented landscapes--empirical evidence for the importance of habitat amount for species persistence.PloS one · 2011Article
- MHC gene copy number variation in Tasmanian devils: implications for the spread of a contagious cancer.Proceedings. Biological sciences · 2010Article
- Trans-species polymorphism of the Mhc class II DRB-like gene in banded penguins (genus Spheniscus).Immunogenetics · 2009Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundResearch on the genetic architecture and diversity of the MHC has focused mainly on eutherian mammals, birds and fish. So far, studies on model marsupials used in laboratory investigations indicated very little or even no variation in MHC class II genes. However, natural levels of diversity and selection are unknown in marsupials as studies on wild populations are virtually absent. We used two endemic South American mouse opossums, Gracilinanus microtarsus and Marmosops incanus, to investigate characteristic features of MHC selection. This study is the first investigation of MHC selection in free-ranging Neotropical marsupials. In addition, the evolutionary history of MHC lineages within the group of marsupials was examined.
resultsG. microtarsus showed extensive levels of MHC diversity within and among individuals as 47 MHC-DAB alleles and high levels of sequence divergence were detected at a minimum of four loci. Positively selected codon sites were identified, of which most were congruent with human antigen binding sites. The diversity in M. incanus was rather low with only eight observed alleles at presumably two loci. However, these alleles also revealed high sequence divergence. Again, positive selection was identified on specific codon sites, all congruent with human ABS and with positively selected sites observed in G. microtarsus. In a phylogenetic comparison alleles of M. incanus interspersed widely within alleles of G. microtarsus with four alleles being present in both species.
conclusionOur investigations revealed extensive MHC class II polymorphism in a natural marsupial population, contrary to previous assumptions. Furthermore, our study confirms for the first time in marsupials the presence of three characteristic features common at MHC loci of eutherian mammals, birds and fish: large allelic sequence divergence, positive selection on specific sites and trans-specific polymorphism.
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