Evidence map›Paper›PMID 18533988›Full record

ArticleVirology journal2008

Complete genome of a European hepatitis C virus subtype 1g isolate: phylogenetic and genetic analyses.

Maria A Bracho, Verónica Saludes, Elisa Martró, Ana Bargalló, Fernando González-Candelas, Vicent Ausina

Abstract read
In one paragraph

Article in Virology journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Maria A BrachoInstitut Cavanilles de Biodiversitat i Biologia Evolutiva, Universitat de València, Paterna, València, Spain. alma.bracho@uv.es
Verónica Saludes
Elisa Martró
Ana Bargalló
Fernando González-Candelas
Vicent Ausina

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHepatitis C virus isolates have been classified into six main genotypes and a variable number of subtypes within each genotype, mainly based on phylogenetic analysis. Analyses of the genetic relationship among genotypes and subtypes are more reliable when complete genome sequences (or at least the full coding region) are used; however, so far 31 of 80 confirmed or proposed subtypes have at least one complete genome available. Of these, 20 correspond to confirmed subtypes of epidemic interest.

resultsWe present and analyse the first complete genome sequence of a HCV subtype 1g isolate. Phylogenetic and genetic distance analyses reveal that HCV-1g is the most divergent subtype among the HCV-1 confirmed subtypes. Potential genomic recombination events between genotypes or subtype 1 genomes were ruled out. We demonstrate phylogenetic congruence of previously deposited partial sequences of HCV-1g with respect to our sequence.

conclusionIn light of this, we propose changing the current status of its subtype-specific designation from provisional to confirmed.

Indexed as

Genome, ViralSequence Analysis, DNABase SequenceGenotypeHepacivirusMolecular Sequence DataPhylogenyRNA, ViralSequence HomologyRNA, Viral

Identifiers

PMID18533988
PMCPMC2438343

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.