ArticleOrganic letters2008
A nonafluoro nucleoside as a sensitive 19f NMR probe of nucleic acid conformation.
Article in Organic letters, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Immobilized Nucleoside 2'-Deoxyribosyltransferases from Extremophiles for Nucleoside Biocatalysis.ACS omega · 2025Article
- Probing juxtaposed G-quadruplex and hairpin motifs using a responsive nucleoside probe: a unique scaffold for chemotherapy.Chemical science · 2023Article
- Synthesis of Trifluoromethylated Purine Ribonucleotides and Their Evaluation asThe Journal of organic chemistry · 2020Article
- Synthesis and applications of theranostic oligonucleotides carrying multiple fluorine atoms.Theranostics · 2020Review
- AromaticNature methods · 2019Article
- Investigation of higher-order RNA G-quadruplex structures in vitro and in living cells byNature protocols · 2018Article
- Studying DNA G-Quadruplex Aptamer byACS omega · 2017Article
- Characterization of human telomere RNA G-quadruplex structures in vitro and in living cells using 19F NMR spectroscopy.Nucleic acids research · 2017Article
- Expanding the Scope of 2'-SCF3 Modified RNA.Chemistry (Weinheim an der Bergstrasse, Germany) · 2015Article
- Natural-like replication of an unnatural base pair for the expansion of the genetic alphabet and biotechnology applications.Journal of the American Chemical Society · 2014Article
- New frontiers and developing applications in 19F NMR.Progress in nuclear magnetic resonance spectroscopy · 2013Review
- 2'-SCF3 uridine-a powerful label for probing structure and function of RNA by 19F NMR spectroscopy.Angewandte Chemie (International ed. in English) · 2012Article
- 5-Fluoro pyrimidines: labels to probe DNA and RNA secondary structures by 1D 19F NMR spectroscopy.Nucleic acids research · 2009Article
- In situ monitoring of backbone thioester exchange by 19F NMR.Chembiochem : a European journal of chemical biology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
A nucleoside carrying a perfluorinated tert-butyl group ( 4) was prepared by a Sonogashira coupling of 5-iodo-2'-deoxyuridine with 4,4,4-trifluoro-3,3-bis(trifluoromethyl)-1-butyne in nearly quantitative yield and subsequently incorporated into DNA oligomers. Thermal denaturation studies showed that 4 had a negligible effect on duplex stability when compared to thymidine. Transition from single strand to duplex was monitored by (19)F NMR spectroscopy at micromolar concentrations of oligomers, demonstrating the sensitivity of 4 as an NMR reporter nucleoside.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.