ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2008
Human bocavirus in children hospitalized for acute gastroenteritis: a case-control study.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
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Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Risk of acute gastroenteritis associated with human bocavirus infection in children: A systematic review and meta-analysis.PloS one · 2017Pooled it
- Trial
- Revealing the hidden burden: wastewater-based epidemiology for underreported and emerging infectious diseases in communities.Environmental monitoring and assessment · 2026Review
- Tracking the occurrence and fate of human bocavirus 2 in municipal wastewater from a small city.Molecular biology reports · 2026Article
- Exploring evidence from cells to clinics: is human bocavirus a gastrointestinal pathogen or just a risk factor?Archives of virology · 2025Review
- Wastewater-based epidemiology applied at the building-level reveals distinct virome profiles based on the age of the contributing individuals.Human genomics · 2024Article
- Nausea, Vomiting, and Diarrhea Are Common in Community-Acquired Acute Viral Respiratory Illness.Digestive diseases and sciences · 2023Article
- Human Bocavirus in Brazil: Molecular Epidemiology, Viral Load and Co-Infections.Pathogens (Basel, Switzerland) · 2020Article
- Article
- Detection of different enteric viruses in children with diarrheal disease: evidence of the high frequency of mixed infections.Access microbiology · 2019Article
- Advances in Diagnostic Approaches for Viral Etiologies of Diarrhea: From the Lab to the Field.Frontiers in microbiology · 2019Review
- Case-Control Assessment of the Roles of Noroviruses, Human Bocaviruses 2, 3, and 4, and Novel Polyomaviruses and Astroviruses in Acute Childhood Diarrhea.Journal of the Pediatric Infectious Diseases Society · 2017Article
- Latent infection of human bocavirus accompanied by flare of chronic cough, fatigue and episodes of viral replication in an immunocompetent adult patient, Cologne, Germany.JMM case reports · 2016Article
- Determination of cut-off cycle threshold values in routine RT-PCR assays to assist differential diagnosis of norovirus in children hospitalized for acute gastroenteritis.Epidemiology and infection · 2015Article
- Clinical epidemiology and molecular profiling of human bocavirus in faecal samples from children with diarrhoea in Guangzhou, China.Epidemiology and infection · 2015Article
- Viral etiologies of acute dehydrating gastroenteritis in pakistani children: confounding role of parechoviruses.Viruses · 2015Article
- Salivirus in Children and Its Association with Childhood Acute Gastroenteritis: A Paired Case-Control Study.PloS one · 2015Article
- Detection of human bocavirus in children with acute respiratory tract infections in Lanzhou and Nanjing, China.Biomedical and environmental sciences : BES · 2014Article
- Human bocaviruses are commonly found in stools of hospitalized children without causal association to acute gastroenteritis.European journal of pediatrics · 2014Article
- Etiology of viral gastroenteritis in children <5 years of age in the United States, 2008-2009.The Journal of infectious diseases · 2013Article
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13 authors.
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Abstract
backgroundHuman bocavirus (HBoV) was recently discovered in children with respiratory tract disease and gastroenteritis. The causative role of HBoV in human gastroenteritis remains uncertain, and, to our knowledge, no previous case-control study has studied the relationship between HBoV and gastroenteritis.
methodsWe conducted a case-control study that examined stool samples from 397 children with diarrhea and from 115 asymptomatic control subjects. HBoV was detected using polymerase chain reaction. Real-time polymerase chain reaction was used to quantify the HBoV loads in case and control groups. Common enteric viruses were examined using enzyme-linked immunosorbent assays, polymerase chain reaction, and reverse-transcription polymerase chain reaction.
resultsAt least 1 viral agent was discovered in 60.2% of cases. HBoV was detected in 14 samples, and 9 were coinfected with either rotavirus (7 of 14 samples) or human calicivirus (2 of 14). Many (8 [57.1%] of 14) of the HBoV infections occurred during September-December 2006. Most (12 [85.7%]) of the HBoV-infected children were 7-18 months of age. The percentage of children with HBoV infection did not differ significantly between case patients and control subjects (3.5% vs. 3.5%), and the statistical analysis did not support a correlation between HBoV infection and more-severe clinical symptoms. The viral load differences between the 2 groups were not statistically significant (P = .09, by log-normal Student's t test). In addition, the VP1/VP2 partial gene of HBoV from case patients and control subjects showed minimal sequence variation.
conclusionsA single genetic lineage of HBoV was revealed in persons in China. Despite its high prevalence in stool samples, our study does not support a causative role of HBoV in gastroenteritis.
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