ReviewWorld journal of gastroenterology2008
Etiopathogenesis of primary sclerosing cholangitis.
Review in World journal of gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 86 citations in OpenAlex.
- Long-term Outcomes Following Colectomy and Liver Transplantation for Inflammatory Bowel Disease With Primary Sclerosing Cholangitis.Annals of surgery · 2026Article
- Immune-mediated cholangiopathies in children: the need to better understand the pathophysiology for finding the future possible treatment targets.Frontiers in immunology · 2023Review
- Cholangiocyte organoids from human bile retain a local phenotype and can repopulate bile ducts in vitro.Clinical and translational medicine · 2021Article
- Regional Differences in Human Biliary Tissues and Corresponding In Vitro-Derived Organoids.Hepatology (Baltimore, Md.) · 2021Article
- Administration of Human MSC-Derived Extracellular Vesicles for the Treatment of Primary Sclerosing Cholangitis: Preclinical Data in MDR2 Knockout Mice.International journal of molecular sciences · 2020Article
- Gut Microbiome of Children and Adolescents With Primary Sclerosing Cholangitis in Association With Ulcerative Colitis.Frontiers in immunology · 2020Article
- Sulphite oxidase (SO) - a mitochondrial autoantigen as target for humoral and cellular immune reactions in primary sclerosing cholangitis.BMC gastroenterology · 2018Article
- Pharmacological interventions for primary sclerosing cholangitis: an attempted network meta-analysis.The Cochrane database of systematic reviews · 2017Review
- TGR5: pathogenetic role and/or therapeutic target in fibrosing cholangitis?Clinical reviews in allergy & immunology · 2015Review
- Risk factors and outcome in patients with primary sclerosing cholangitis with persistent biliary candidiasis.BMC infectious diseases · 2014Article
- A morphological and immunohistochemical study of the effects of prednisolone or ursodeoxycholic acid on liver histology in feline lymphocytic cholangitis.Journal of feline medicine and surgery · 2014Article
- Mechanisms of tissue injury in autoimmune liver diseases.Seminars in immunopathology · 2014Review
- Characterization of animal models for primary sclerosing cholangitis (PSC).Journal of hepatology · 2014Review
- A Review of the Challenges Associated with the Diagnosis and Therapy of Primary Sclerosing Cholangitis.Journal of clinical and translational hepatology · 2014Review
- In situ characterization of intrahepatic non-parenchymal cells in PSC reveals phenotypic patterns associated with disease severity.PloS one · 2014Article
- Sclerosing cholangitis in baboons (Papio spp) resembling primary sclerosing cholangitis of humans.Veterinary pathology · 2012Article
- Pathogenesis of primary sclerosing cholangitis.Best practice & research. Clinical gastroenterology · 2011Review
- Cutting edge issues in primary sclerosing cholangitis.Clinical reviews in allergy & immunology · 2011Article
- Genetic polymorphisms of matrix metalloproteinase 3 in primary sclerosing cholangitis.Liver international : official journal of the International Association for the Study of the Liver · 2011Article
- Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL, and CARD9.Hepatology (Baltimore, Md.) · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown etiology but lymphocytic portal tract infiltration is suggestive of an immune-mediated basis for this disease. Associations with inflammatory bowel disease (IBD) especially ulcerative colitis (UC), and with particular autoimmune diseases, as well as the genetic associations further suggest PSC may be an immune-mediated disease. The immunogenetics of PSC have been the subject of active research and several HLA and non-HLA associated genes have been implicated in the development of the disease. Lymphocytes derived from the inflamed gut may enter the liver via the enterohepatic circulation to cause hepatic disease. PSC may be triggered in genetically susceptible individuals by infections or toxins entering the portal circulation through a permeable colon and hence evoking an abnormal immune response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.