ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2008
Epidemiology of bacteremia episodes in a single center: increase in Gram-negative isolates, antibiotics resistance, and patient age.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Epidemiology of bloodstream infections and infective endocarditis: new insights on typical species and echocardiography screening.Open heart · 2026Article
- Vesicle-Mediated Transfer of CTX-M β-Lactamase Genes and Proteins Confers Ampicillin Resistance inInternational journal of molecular sciences · 2025Article
- Carbapenem-Resistant Gram-Negative Bacteria in Hospitalized Patients: A Five-Year Surveillance in Italy.Infectious disease reports · 2025Article
- Prevalence and Antibiotic Susceptibility of Pathogenic Enterobacteria Strains from Three Biotopes in the City of Ouagadougou (Burkina Faso).Infection and drug resistance · 2024Article
- ComparativeMicrobiology spectrum · 2022Article
- Bloodstream infections in older population: epidemiology, outcome, and impact of multidrug resistance.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021Article
- An analysis of the incidence, causes and preventative approaches to gram-negative bloodstream infections of hepatopancreatobiliary origin.Journal of infection prevention · 2021Article
- The Clinical and Molecular Epidemiology of Noncarbapenemase-Producing Carbapenem-ResistantOpen forum infectious diseases · 2020Article
- Amoxicillin/clavulanic acid+aminoglycoside as empirical antibiotic treatment in severe community-acquired infections with diagnostic uncertainty.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019Observational
- Multidrug-Resistant Gram-Negative Bacilli: A Retrospective Study of Trends in a Tertiary Healthcare Unit.Medicina (Kaunas, Lithuania) · 2018Observational
- Bacteraemia in emergency departments: effective antibiotic reassessment is associated with a better outcome.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Article
- Incidence of bloodstream infections: a nationwide surveillance of acute care hospitals in Switzerland 2008-2014.BMJ open · 2017Article
- Clinical and Epidemiological Significance of Carbapenem Resistance in Acinetobacter baumannii Infections.Antimicrobial agents and chemotherapy · 2016Article
- Timing of positive blood samples does not differentiate pathogens causing healthcare-associated from community-acquired bloodstream infections in children in England: a linked retrospective cohort study.Epidemiology and infection · 2015Article
- Long-term effectiveness of infection and antibiotic control programs on the transmission of carbapenem-resistant Acinetobacter calcoaceticus-Acinetobacter baumannii complex in central Taiwan.Medecine et maladies infectieuses · 2015Article
- Traumatic injury, early gene expression, and gram-negative bacteremia.Critical care medicine · 2014Article
- Epidemiology of bacteremia caused by uncommon non-fermentative gram-negative bacteria.BMC infectious diseases · 2013Article
- Influence of referral bias on the clinical characteristics of patients with Gram-negative bloodstream infection.Epidemiology and infection · 2011Article
- Multidrug-resistant Acinetobacter spp.: increasingly problematic nosocomial pathogens.Yonsei medical journal · 2011Review
- Predictors of in-hospital mortality in elderly patients with bacteraemia admitted to an Internal Medicine ward.International archives of medicine · 2011Article
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6 authors.
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Abstract
Increased resistance among isolates causing bacteremia constitutes a major challenge to medical practitioners and institutions. Variability between institutes is substantial, and requires the individual analysis of local trends. An eight-year (1997-2004) surveillance study of episodes of bacteremia was conducted in an 850-bed university hospital in central Israel. Trends of incidence, resistance, age, and mortality were analyzed. We studied 6,096 patient-unique episodes of bacteremia, of which, 2,722 (45.3%) were nosocomial and 523 (9.2%) involved children less than 18 years of age. The overall incidence of bacteremia episodes has increased over the study years by 39% and the patient mean age by 7.5 years. Gram-negative organisms accounted for 72% of hospital-acquired cases and 69% of community-acquired cases. There was a substantial increase in the incidence of nosocomial episodes, predominantly due to Gram-negative isolates, mainly Acinetobacter baumannii, Klebsiella pneumoniae, and Escherichia coli. Increased resistance to broad-spectrum antibiotics was noted among Gram-negative organisms, including quinolones (in K. pneumoniae), imipenem (A. baumannii and P. aeruginosa), piperacillin-tazobactam (K. pneumoniae), and amikacin (A. baumannii and P. aeruginosa). Increased resistance to oxacillin among coagulase-negative staphylococci was also noted. The all-cause mortality rates showed a significant rise. The patient age, intensive care unit (ICU) stay, and hospital acquisition were independently associated with mortality. We describe an increase in the incidence and resistance of Gram-negative organisms causing bacteremia and concomitant ageing of the patients with bacteremia. Similar patterns have been reported from other localities, and are of real concern.
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