ArticleInfectious diseases in obstetrics and gynecology2008
Tetracycline effects on Candida albicans virulence factors.
Article in Infectious diseases in obstetrics and gynecology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
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- Effect of Lactiplantibacillus Plantarum THK-J112 Against Candida Overgrowth in Acne Complications.Probiotics and antimicrobial proteins · 2026Article
- NRGCNMDA: Microbe-Drug Association Prediction Based on Residual Graph Convolutional Networks and Conditional Random Fields.Interdisciplinary sciences, computational life sciences · 2025Article
- The gut mycobiome: The overlooked constituent of clinical outcomes and treatment complications in patients with cancer and other immunosuppressive conditions.PLoS pathogens · 2020Article
- A Combination of Polybacterial MV140 andFrontiers in immunology · 2020Article
- Sarecycline: a narrow spectrum tetracycline for the treatment of moderate-to-severe acne vulgaris.Future microbiology · 2019Review
- Microbiological Profile of Sarecycline, a Novel Targeted Spectrum Tetracycline for the Treatment of Acne Vulgaris.Antimicrobial agents and chemotherapy · 2019Article
- In vitro analysis of finasteride activity against Candida albicans urinary biofilm formation and filamentation.Antimicrobial agents and chemotherapy · 2014Article
- Heparin-benzyl alcohol enhancement of biofilms formation and antifungal susceptibility of vaginal Candida species isolated from pregnant and nonpregnant Saudi women.Bioinformation · 2013Article
- Do Candida spp. "read" Nietzsche? Can xenobiotics modulate their aggressiveness? Proposition that chemicals may interfere in their virulence attributes.Mycopathologia · 2012Article
- Sodium choleate (NaCho) effects on Candida albicans: implications for its role as a gastrointestinal tract inhabitant.Mycopathologia · 2010Article
- Hemolytic activities of the Candida species in liquid medium.The Eurasian journal of medicine · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectTo determine if tetracycline, previously reported to increase the probability of developing symptomatic vaginal yeast infections, has a direct effect on Candida albicans growth or induction of virulent phenotypes.
methodIn vitro, clinical isolates of yeast were cultivated with sublethal concentrations of tetracycline and yeast cell counts, hyphal formation, drug efflux pump activity, biofilm production, and hemolysin production were determined by previously reported methods.
resultsTetracycline concentrations above 150 microg/mL inhibited Candida albicans, but at submicrogram/mL, a modest growth increase during the early hours of the growth curve was observed. Tetracycline did not inhibit hyphal formation at sublethal concentrations. Hypha formation appeared augmented by exposure to tetracycline in the presence of chemically defined medium and especially in the presence of human serum. Efflux pump CDR1 was upregulated and a nonsignificant trend toward increased biofilm formation was noted.
conclusionTetracycline appears to have a small growth enhancing effect and may influence virulence through augmentation of hypha formation, and a modest effect on drug efflux and biofilm formation, although tetracycline did not affect hemolysin. It is not clear if the magnitude of the effect is sufficient to attribute vaginitis following tetracycline treatment to direct action of tetracycline on yeast.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.