ArticleGenes and immunity2008
Ly49 cluster sequence analysis in a mouse model of diabetes: an expanded repertoire of activating receptors in the NOD genome.
Article in Genes and immunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Cis-regulatory evolution of the recently expanded Ly49 gene family.Nature communications · 2024Article
- Synergized regulation of NK cell education by NKG2A and specific Ly49 family members.Nature communications · 2019Article
- Regulation of Diabetogenic Immunity by IL-15-Activated Regulatory CD8 T Cells in Type 1 Diabetes.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Variegated Transcription of the WC1 Hybrid PRR/Co-Receptor Genes by Individual γδ T Cells and Correlation With Pathogen Responsiveness.Frontiers in immunology · 2018Article
- The Four-Way Stop Sign: Viruses, 12-Lipoxygenase, Islets, and Natural Killer Cells in Type 1 Diabetes Progression.Frontiers in endocrinology · 2017Article
- Uterine Natural Killer Cells: Functional Distinctions and Influence on Pregnancy in Humans and Mice.Frontiers in immunology · 2017Review
- Nucleosome Presence at AML-1 Binding Sites Inversely Correlates with Ly49 Expression: Revelations from an Informatics Analysis of Nucleosomes and Immune Cell Transcription Factors.PLoS computational biology · 2016Article
- The distal upstream promoter in Ly49 genes, Pro1, is active in mature NK cells and T cells, does not require TATA boxes, and displays enhancer activity.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- The mouse NKR-P1B:Clr-b recognition system is a negative regulator of innate immune responses.Blood · 2015Article
- Probabilistic bidirectional promoter switches: noncoding RNA takes control.Molecular therapy. Nucleic acids · 2014Article
- Transcriptional and epigenetic networks of helper T and innate lymphoid cells.Immunological reviews · 2014Review
- The activating Ly49W and inhibitory Ly49G NK cell receptors display similar affinities for identical MHC class I ligands.Immunogenetics · 2014Article
- Ly49 receptors: innate and adaptive immune paradigms.Frontiers in immunology · 2014Review
- Role of inositol phospholipid signaling in natural killer cell biology.Frontiers in immunology · 2013Article
- The non-obese diabetic mouse sequence, annotation and variation resource: an aid for investigating type 1 diabetes.Database : the journal of biological databases and curation · 2013Article
- The ly49 gene family. A brief guide to the nomenclature, genetics, and role in intracellular infection.Frontiers in immunology · 2013Article
- Impaired natural killer cell self-education and "missing-self" responses in Ly49-deficient mice.Blood · 2012Article
- Genetic dissection of NK cell responses.Frontiers in immunology · 2012Article
- Article
- Structural variation of the mouse natural killer gene complex.Genes and immunity · 2010Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
The mouse Ly49 and human killer cell immunoglobulin-like receptors (KIR) gene clusters encode activating and inhibitory class I MHC receptors on natural killer (NK) cells. A direct correlation between the presence of multiple activating KIR and various human autoimmune diseases including diabetes has been shown. Previous studies have implicated NK cell receptors in the development of diabetes in the non-obese diabetic (NOD) inbred mouse strain. To assess the contribution of Ly49 to NOD disease acceleration the Ly49 gene cluster of these mice was sequenced. Remarkably, the NOD Ly49 haplotype encodes the largest haplotype and the most functional activating Ly49 of any known mouse strain. These activating Ly49 include three Ly49p-related and two Ly49h-related genes. The NOD cluster contains large regions highly homologous to both C57BL/6 and 129 haplotypes, suggesting unequal crossing over as a mechanism of Ly49 haplotype evolution. Interestingly, the 129-like region has duplicated in the NOD genome. Thus, the NOD Ly49 cluster is a unique mix of elements seen in previously characterized Ly49 haplotypes resulting in a disproportionately large number of functional activating Ly49 genes. Finally, the functionality of activating Ly49 in NOD mice was confirmed in cytotoxicity assays.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.