ReviewKidney international2008
Does Fgf23-klotho activity influence vascular and soft tissue calcification through regulating mineral ion metabolism?
Review in Kidney international, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 72 citations in OpenAlex.
- Band keratopathy and conjunctival calcification in end-stage kidney disease: epidemiology, pathophysiology and clinical management.Clinical kidney journal · 2026Review
- Osteoporosis therapies and coronary risk: insights from vascular calcification biology and sclerostin signaling.Frontiers in endocrinology · 2026Review
- Article
- A Sole Case of the FGF23 Gene Mutation c.202A>G (p.Thr68Ala) Associated with Multiple Severe Vascular Aneurysms and a Hyperphosphatemic Variant of Tumoral Calcinosis-A Case Report.Life (Basel, Switzerland) · 2024Article
- Article
- Hepatocyte Nuclear Factor-1α Increases Fibrinogen Gene Expression in Liver and Plasma Fibrinogen Concentration in Rats with Experimental Chronic Renal Failure.International journal of molecular sciences · 2023Article
- Characteristics and complications of fracture in older adults with chronic kidney disease: a cross-sectional study.Journal of orthopaedic surgery and research · 2022Article
- Arterial Stiffness: A Focus on Vascular Calcification and Its Link to Bone Mineralization.Arteriosclerosis, thrombosis, and vascular biology · 2020Review
- Klotho/FGF23 and Wnt Signaling as Important Players in the Comorbidities Associated with Chronic Kidney Disease.Toxins · 2020Review
- Research Progress on the Relationship between Coronary Artery Calcification and Chronic Renal Failure.Chinese medical journal · 2018Review
- Saturated phosphatidic acids mediate saturated fatty acid-induced vascular calcification and lipotoxicity.The Journal of clinical investigation · 2015Article
- Fibroblast growth factor 23: associations with cardiovascular disease and mortality in chronic kidney disease.International urology and nephrology · 2014Review
- Is 24,25(OH)D level really high in dialysis patients with high FGF23 levels?International urology and nephrology · 2012Review
- Protective roles of DMP1 in high phosphate homeostasis.PloS one · 2012Article
- Lack of association of Klotho gene variants with valvular and vascular calcification in Caucasians: a candidate gene study of the Framingham Offspring Cohort.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2011Article
- Osteo-renal regulation of systemic phosphate metabolism.IUBMB life · 2011Review
- The dualistic role of vitamin D in vascular calcifications.Kidney international · 2011Review
- Vascular and valvular calcification in chronic peritoneal dialysis patients.International journal of nephrology · 2011Article
- Ablation of systemic phosphate-regulating gene fibroblast growth factor 23 (Fgf23) compromises the dentoalveolar complex.Anatomical record (Hoboken, N.J. : 2007) · 2010Article
- In vivo genetic evidence for suppressing vascular and soft-tissue calcification through the reduction of serum phosphate levels, even in the presence of high serum calcium and 1,25-dihydroxyvitamin d levels.Circulation. Cardiovascular genetics · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Recent studies describe a novel role of fibroblast growth factor-23 (Fgf23)-klotho activity in the systemic regulation of calcium and phosphate homeostasis. Both Fgf23 and klotho ablated mice develop extensive vascular and soft tissue calcification. Inability to clear the required amount of phosphate by the kidney, due to the absence of Fgf23-klotho activity, leads to increased accumulation of serum phosphate in these genetically modified mice, causing extensive calcification. Serum calcium and 1,25 hydroxyvitamin D levels are also elevated in both Fgf23 and klotho ablated mice. Moreover, increased sodium phosphate co-transporter activity in both Fgf23 and klotho ablated mice increases renal phosphate reabsorption which in turn can facilitate calcification. Collectively, these observations bring new insights into our understanding of the roles of the Fgf23-klotho axis in the development of vascular and soft tissue calcification.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.