ArticleJournal of neurophysiology2008
Prolonged exposure to NMDAR antagonist suppresses inhibitory synaptic transmission in prefrontal cortex.
Article in Journal of neurophysiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 109 citations in OpenAlex.
- Reduced auditory evoked gamma-band response and schizophrenia-like clinical symptoms under subanesthetic ketamine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Trial
- Activation of prefrontal parvalbumin interneurons ameliorates working memory deficit even under clinically comparable antipsychotic treatment in a mouse model of schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- The impact of the mesoprefrontal dopaminergic system on the maturation of interneurons in the murine prefrontal cortex.Frontiers in neuroscience · 2024Article
- A Network Model of the Modulation of γ Oscillations by NMDA Receptors in Cerebral Cortex.eNeuro · 2023Article
- Suppression of Low-Frequency Gamma Oscillations by Activation of 40-Hz Oscillation.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Reproducing the dopamine pathophysiology of schizophrenia and approaches to ameliorate it: a translational imaging study with ketamine.Molecular psychiatry · 2021Article
- A Selective Review of the Excitatory-Inhibitory Imbalance in Schizophrenia: Underlying Biology, Genetics, Microcircuits, and Symptoms.Frontiers in cell and developmental biology · 2021Review
- Alterations in cortical interneurons and cognitive function in schizophrenia.Neurobiology of disease · 2019Review
- Ketamine-Treatment During Late Adolescence Impairs Inhibitory Synaptic Transmission in the Prefrontal Cortex and Working Memory in Adult Rats.Frontiers in cellular neuroscience · 2019Article
- Neurophysiology and Regulation of the Balance Between Excitation and Inhibition in Neocortical Circuits.Biological psychiatry · 2017Review
- Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
- Prevalence and clinical characteristics of serum neuronal cell surface antibodies in first-episode psychosis: a case-control study.The lancet. Psychiatry · 2017Article
- A Novel Multisensory Integration Task Reveals Robust Deficits in Rodent Models of Schizophrenia: Converging Evidence for Remediation via Nicotinic Receptor Stimulation of Inhibitory Transmission in the Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Risks Associated with Misuse of Ketamine as a Rapid-Acting Antidepressant.Neuroscience bulletin · 2016Review
- Regional brain dysregulation of Ca(2+)-handling systems in ketamine-induced rat model of experimental psychosis.Cell and tissue research · 2016Article
- GABA abnormalities in schizophrenia: a methodological review of in vivo studies.Schizophrenia research · 2015Review
- The impact of NMDA receptor hypofunction on GABAergic neurons in the pathophysiology of schizophrenia.Schizophrenia research · 2015Review
- Spontaneous Gamma Activity in Schizophrenia.JAMA psychiatry · 2015Article
- Loss of phenotype of parvalbumin interneurons in rat prefrontal cortex is involved in antidepressant- and propsychotic-like behaviors following acute and repeated ketamine administration.Molecular neurobiology · 2015Article
- Convergence of genetic and environmental factors on parvalbumin-positive interneurons in schizophrenia.Frontiers in behavioral neuroscience · 2013Review
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3 authors at 1 institution in 1 country.
Funding
Abstract
Postmortem studies have shown that schizophrenia produces a reduction in the 67-kilodalton isoform of glutamic acid decarboxylase (GAD67), a key enzyme for gamma-aminobutyric acid (GABA) synthesis. N-methyl-d-aspartate receptor (NMDAR) antagonists have been extensively used to study schizophrenia because they can induce many aspects of the disease, including the decrease in GAD67. It is generally thought that this reduction in GAD implies a reduction in functional inhibition, but direct evidence had been lacking. We have therefore performed physiological studies in slices of prefrontal cortex taken from rats treated with the NMDAR antagonist ketamine. Both frequency and amplitude of miniature inhibitory postsynaptic currents were reduced. Consistent with a reduction of inhibition, we observed an increase in postsynaptic excitability. The increased excitability is likely to result from disinhibition because miniature excitatory postsynaptic current properties and intrinsic excitability were not changed. Ketamine did not affect inhibition or GAD levels in young rats, indicating a developmental regulation that may be related to the developmental increase in ketamine sensitivity that occurs in humans. Our results show that NMDAR antagonist produces biochemical changes in the GABA system that lead to a functional disinhibition. Such disinhibition would be expected to decrease gamma oscillations, which are reduced in schizophrenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.