ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Axonal injury and regeneration in the adult brain of Drosophila.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed, 108 citations in OpenAlex.
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- Semi-automatic geometrical reconstruction and analysis of filopodia dynamics in 4D two-photon microscopy images.BMC bioinformatics · 2026Article
- The Drosophila adult brain: short overview of structure, function, and resources Graphical Review Paper.Current research in insect science · 2025Review
- A Pvr-AP-1-Mmp1 signaling pathway is activated in astrocytes upon traumatic brain injury.eLife · 2024Article
- TBI and Tau Loss of Function Both Affect Naïve Ethanol Sensitivity inInternational journal of molecular sciences · 2024Article
- Adult neurogenesis does not explain the extensive post-eclosion growth ofRoyal Society open science · 2023Article
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- What Happens in TBI? A Wide Talk on Animal Models and Future Perspective.Current neuropharmacology · 2023Review
- Microengineered devices enable long-term imaging of the ventral nerve cord in behaving adult Drosophila.Nature communications · 2022Article
- Insights into nervous system repair from the fruit fly.Neuronal signaling · 2022Review
- Drosophila as a model to explore secondary injury cascades after traumatic brain injury.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2021Review
- A molecular toolkit for superorganisms.Trends in genetics : TIG · 2021Review
- Hydra vulgaris shows stable responses to thermal stimulation despite large changes in the number of neurons.iScience · 2021Article
- Modeling Neurodegenerative Disorders inInternational journal of molecular sciences · 2020Review
- Structural and Functional Plasticity in the Regenerating Olfactory System of the Migratory Locust.Frontiers in physiology · 2020Review
- Temporal Control of Axonal Transport: The Extreme Case of Organismal Ageing.Frontiers in cellular neuroscience · 2019Review
- Article
- Tissue and cellular rigidity and mechanosensitive signaling activation in Alexander disease.Nature communications · 2018Article
- Single-cell Resolution Fluorescence Live Imaging of Drosophila Circadian Clocks in Larval Brain Culture.Journal of visualized experiments : JoVE · 2018Article
1 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 2 institutions in 3 countries.
Funding
Abstract
Drosophila melanogaster is a leading genetic model system in nervous system development and disease research. Using the power of fly genetics in traumatic axonal injury research will significantly speed up the characterization of molecular processes that control axonal regeneration in the CNS. We developed a versatile and physiologically robust preparation for the long-term culture of the whole Drosophila brain. We use this method to develop a novel Drosophila model for CNS axonal injury and regeneration. We first show that, similar to mammalian CNS axons, injured adult wild-type fly CNS axons fail to regenerate, whereas adult-specific enhancement of protein kinase A activity increases the regenerative capacity of lesioned neurons. Combined, these observations suggest conservation of neuronal regeneration mechanisms after injury. We next exploit this model to explore pathways that induce robust regeneration and find that adult-specific activation of c-Jun N-terminal protein kinase signaling is sufficient for de novo CNS axonal regeneration injury, including the growth of new axons past the lesion site and into the normal target area.
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Registered trials
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