ArticleJournal of virology2008
Regulation of cytokine production by virus-specific CD8 T cells in the lungs.
Article in Journal of virology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 30 citations in OpenAlex.
- Genetic absence of PD-L1 does not restore CD8Journal of virology · 2024Article
- Review
- Pre-existing neutralizing antibodies prevent CD8 T cell-mediated immunopathology following respiratory syncytial virus infection.Mucosal immunology · 2020Article
- Vaccination with a Single-Cycle Respiratory Syncytial Virus Is Immunogenic and Protective in Mice.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Identification of Novel Respiratory Syncytial Virus CD4ImmunoHorizons · 2019Article
- Reining in the CD8+ T cell: Respiratory virus infection and PD-1-mediated T-cell impairment.PLoS pathogens · 2019Review
- The CD8 T Cell Response to Respiratory Virus Infections.Frontiers in immunology · 2018Review
- Lung CD8+ T Cell Impairment Occurs during Human Metapneumovirus Infection despite Virus-Like Particle Induction of Functional CD8+ T Cells.Journal of virology · 2015Article
- The effector T cell response to influenza infection.Current topics in microbiology and immunology · 2015Review
- Determining the breadth of the respiratory syncytial virus-specific T cell response.Journal of virology · 2014Article
- The increased type-1 and type-2 chemokine levels in children with acute RSV infection alter the development of adaptive immune responses.BioMed research international · 2014Article
- Vaccine-elicited CD8+ T cells protect against respiratory syncytial virus strain A2-line19F-induced pathogenesis in BALB/c mice.Journal of virology · 2012Article
- Changes in functional but not structural avidity during differentiation of CD8+ effector cells in vivo after virus infection.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- The initial draining lymph node primes the bulk of the CD8 T cell response and influences memory T cell trafficking after a systemic viral infection.PLoS pathogens · 2012Article
- Quantifying antigen-specific CD4 T cells during a viral infection: CD4 T cell responses are larger than we think.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Multiple CD4+ T cell subsets produce immunomodulatory IL-10 during respiratory syncytial virus infection.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Differentiation-dependent differences in murine T cell susceptibility to negative regulation by the lung.American journal of respiratory cell and molecular biology · 2011Article
- Article
- Foxp3+ CD4 regulatory T cells limit pulmonary immunopathology by modulating the CD8 T cell response during respiratory syncytial virus infection.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- T cell epitope specificity and pathogenesis of mouse hepatitis virus-1-induced disease in susceptible and resistant hosts.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Inflammation and the elimination of infected host cells during an immune response often cause local tissue injury and immunopathology, which can disrupt the normal functions of tissues such as the lung. Here, we show that both virus-induced inflammation and the host tissue environment combine to influence the capacity of virus-specific CD4 and CD8 T cells to produce cytokines in various tissues. Decreased production of cytokines, such as IFN-gamma and TNF-alpha, by antigen-specific T cells is more pronounced in peripheral tissues, such as the lung and kidney, than in secondary lymphoid organs, such as the spleen or lymph nodes. We also demonstrate that tissues regulate cytokine production by memory T cells independently of virus infection, as memory T cells that traffic into the lungs of naïve animals exhibit a reduced ability to produce cytokines following direct ex vivo peptide stimulation. Furthermore, we show that cytokine production by antigen-specific memory CD4 and CD8 T cells isolated from the lung parenchyma can be rescued by stimulation with exogenous peptide-pulsed antigen-presenting cells. Our results suggest that the regulation of T-cell cytokine production by peripheral tissues may serve as an important mechanism to prevent immunopathology and preserve normal tissue function.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.