ReviewRespiratory physiology & neurobiology2008
Neurochemical and physiological correlates of a critical period of respiratory development in the rat.
Review in Respiratory physiology & neurobiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 70 citations in OpenAlex.
- Endogenous opioids and the development of the mammalian respiratory control network.American journal of physiology. Lung cellular and molecular physiology · 2025Review
- The critical period: neurochemical and synaptic mechanisms shared by the visual cortex and the brain stem respiratory system.Proceedings. Biological sciences · 2021Review
- Perinatal Hypoxemia and Oxygen Sensing.Comprehensive Physiology · 2021Article
- Maternal Methadone Destabilizes Neonatal Breathing and Desensitizes Neonates to Opioid-Induced Respiratory Frequency Depression.Frontiers in physiology · 2021Article
- Growth and survival characteristics ofAnimal models and experimental medicine · 2020Article
- Phrenic motor neuron loss in an animal model of early onset hypertonia.Journal of neurophysiology · 2020Article
- Seizures in Pre-term Infants Less than 29 Weeks: Incidence, Etiology, and Response to Treatment.Kansas journal of medicine · 2020Article
- Mechanisms underlying a critical period of respiratory development in the rat.Respiratory physiology & neurobiology · 2019Review
- A Critical Evaluation of Current Concepts in Cerebral Palsy.Physiology (Bethesda, Md.) · 2019Review
- Acute and chronic changes in the control of breathing in a rat model of bronchopulmonary dysplasia.American journal of physiology. Lung cellular and molecular physiology · 2019Article
- Pituitary adenylate cyclase-activating polypeptide: Postnatal development in multiple brain stem respiratory-related nuclei in the rat.Respiratory physiology & neurobiology · 2019Article
- Uncovering a critical period of synaptic imbalance during postnatal development of the rat visual cortex: role of brain-derived neurotrophic factor.The Journal of physiology · 2018Article
- Differences in lumbar motor neuron pruning in an animal model of early onset spasticity.Journal of neurophysiology · 2018Article
- Lung-injury depresses glutamatergic synaptic transmission in the nucleus tractus solitarii via discrete age-dependent mechanisms in neonatal rats.Brain, behavior, and immunity · 2018Article
- Effects of neonatal hyperoxia on the critical period of postnatal development of neurochemical expressions in brain stem respiratory-related nuclei in the rat.Physiological reports · 2018Article
- Respiratory dysfunction following neonatal sustained hypoxia exposure during a critical window of brain stem extracellular matrix formation.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- The Consequences of Preterm Birth and Chorioamnionitis on Brainstem Respiratory Centers: Implications for Neurochemical Development and Altered Functions by Inflammation and Prostaglandins.Frontiers in cellular neuroscience · 2018Review
- Chronic central serotonin depletion attenuates ventilation and body temperature in young but not adult Tph2 knockout rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Inhibitory respiratory responses to progesterone and allopregnanolone in newborn rats chronically treated with caffeine.The Journal of physiology · 2016Article
- Role of brain-derived neurotrophic factor in the excitatory-inhibitory imbalance during the critical period of postnatal respiratory development in the rat.Physiological reports · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Despite its vital importance to life, respiration is not mature at birth in mammals, but rather, it undergoes a great deal of growth, refinement, and adjustments postnatally. Many adjustments do not follow smooth paths, but assume abrupt changes during certain postnatal periods that may render the animal less capable of responding to respiratory stressors. The present review focuses on neurochemical and physiological correlates of a critical period of respiratory development in the rat. In addition to an imbalanced expression of reduced excitatory and enhanced inhibitory neurotransmitters, a switch in the expressions of gamma-aminobutyric acid (GABA)A receptor subunits from alpha3 to alpha1 occurs around postnatal day (P)12 in the pre-Bötzinger nucleus and the ventrolateral subnucleus of the solitary tract nucleus. Possible subunit switches in a number of other neurotransmitter receptors are discussed. These neurochemical changes are paralleled by ventilatory adjustments at the end of the second postnatal week. At P13 and under normoxia, respiratory frequency reaches its peak before assuming a gradual fall, and both tidal volume and minute ventilation exhibit a significant rise prior to a plateau or a gradual decline until P21. The response to acute hypoxia is markedly reduced between P12 and P16, being lowest at P13. Thus, the end of the second postnatal week can be considered as a critical period of respiratory development, during which multiple neurochemical and physiological adjustments and switches are orchestrated at the same time, rendering the system extremely dynamic but, at the same time, vulnerable to externally imposed perturbations and insults. The critical period embodies a time of multi-system, multifaceted growth and adjustments. It is a plastic, transitional period that is also a part of the normal development of the respiratory system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.