ArticleThe AAPS journal2008
Mucoadhesive microspheres for gastroretentive delivery of acyclovir: in vitro and in vivo evaluation.
Article in The AAPS journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed.
- The Influence of Chitosan on the Oral Bioavailability of Acyclovir--a Comparative Bioavailability Study in Humans.Pharmaceutical research · 2015Trial
- Intraduodenal administration of intact pea protein effectively reduces food intake in both lean and obese male subjects.PloS one · 2011Trial
- Clinical pharmacokinetics of oral controlled-release 5-fluorocytosine.Antimicrobial agents and chemotherapy · 2010Trial
- Unveiling the molecular mechanism of acyclovir interaction with carbon dots: a DFT approach.Journal of molecular modeling · 2025Article
- Developing a Chitosan/polyvinyl alcohol hydrogel for gastro-retentive release of ranitidine and enhanced anti-ulcerative properties.BMC biotechnology · 2025Article
- Mucus interaction to improve gastrointestinal retention and pharmacokinetics of orally administered nano-drug delivery systems.Journal of nanobiotechnology · 2022Review
- Chitosan and Sodium Alginate Implementation as Pharmaceutical Excipients in Multiple-Unit Particulate Systems.Polymers · 2022Article
- Review
- Evaluation of Ulcer Protective Activity ofEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Potential Applications of Chitosan-Based Nanomaterials to Surpass the Gastrointestinal Physiological Obstacles and Enhance the Intestinal Drug Absorption.Pharmaceutics · 2021Review
- Thiolated Chitosans: A Multi-talented Class of Polymers for Various Applications.Biomacromolecules · 2021Review
- Injectable microfluidic hydrogel microspheres based on chitosan and poly(ethylene glycol) diacrylate (PEGDA) as chondrocyte carriers.RSC advances · 2020Article
- Encapsulation of Black Seed Oil in Alginate Beads as a pH-Sensitive Carrier for Intestine-Targeted Drug Delivery: In Vitro, In Vivo and Ex Vivo Study.Pharmaceutics · 2020Article
- Probing the effect of various lipids and polymer blends on clopidogrel encapsulated floating microcarriers.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2019Article
- In Vitro and In Vivo Test Methods for the Evaluation of Gastroretentive Dosage Forms.Pharmaceutics · 2019Review
- Design of porous EudragitAsian journal of pharmaceutical sciences · 2017Article
- Piperine containing floating microspheres: an approach for drug targeting to the upper gastrointestinal tract.Drug delivery and translational research · 2016Article
- A Janus Mucoadhesive and Omniphobic Device for Gastrointestinal Retention.Advanced healthcare materials · 2016Article
- Preparation, characterization, and potential application of chitosan, chitosan derivatives, and chitosan metal nanoparticles in pharmaceutical drug delivery.Drug design, development and therapy · 2016Review
- Nanoparticle formulation by Büchi B-90 Nano Spray Dryer for oral mucoadhesion.Drug design, development and therapy · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the present investigation was to evaluate the potential use of mucoadhesive microspheres for gastroretentive delivery of acyclovir. Chitosan, thiolated chitosan, Carbopol 71G and Methocel K15M were used as mucoadhesive polymers. Microsphere formulations were prepared using emulsion-chemical crosslinking technique and evaluated in vitro, ex-vivo and in-vivo. Gelatin capsules containing drug powder showed complete dissolution (90.5 +/- 3.6%) in 1 h. The release of drug was prolonged to 12 h (78.8 +/- 3.9) when incorporated into mucoadhesive microspheres. The poor bioavailability of acyclovir is attributed to short retention of its dosage form at the absorption sites (in upper gastrointestinal tract to duodenum and jejunum). The results of mucoadhesion study showed better retention of thiolated chitosan microspheres (8.0 +/- 0.8 h) in duodenal and jejunum regions of intestine. The results of qualitative and quantitative GI distribution study also showed significant higher retention of mucoadhesive microspheres in upper GI tract. Pharmacokinetic study revealed that administration of mucoadhesive microspheres could maintain measurable plasma concentration of acyclovir through 24 h, as compared to 5 h after its administration in solution form. Thiolated chitosan microsphere showed superiority over the other formulations as observed with nearly 4.0-fold higher AUC(0-24) value (1,090 +/- 51 ng h/ml) in comparison to drug solution (281 +/- 28 ng h/ml). Overall, the result indicated prolonged delivery with significant improvement in oral bioavailability of acyclovir from mucoadhesive microspheres due to enhanced retention in the upper GI tract.
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Registered trials
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