ArticlePloS one2008
Adenosine transporter ENT4 is a direct target of EWS/WT1 translocation product and is highly expressed in desmoplastic small round cell tumor.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 56 citations in OpenAlex.
- EWS-WT1 fusion isoforms establish oncogenic programs and therapeutic vulnerabilities in desmoplastic small round cell tumors.Nature communications · 2024Article
- Hypoxia-inducible factor orchestrates adenosine metabolism to promote liver cancer development.Science advances · 2023Article
- Small round cell sarcomas.Nature reviews. Disease primers · 2022Review
- Review of Transporter Substrate, Inhibitor, and Inducer Characteristics of Cladribine.Clinical pharmacokinetics · 2021Review
- Adenosine kinase: An epigenetic modulator in development and disease.Neurochemistry international · 2021Review
- A guide to plasma membrane solute carrier proteins.The FEBS journal · 2021Review
- Therapeutic Potential of NTRK3 Inhibition in Desmoplastic Small Round Cell Tumor.Clinical cancer research : an official journal of the American Association for Cancer Research · 2021Article
- Desmoplastic Small Round Cell Tumor: A Review of Main Molecular Abnormalities and Emerging Therapy.Cancers · 2021Review
- Article
- Dynamic Regulation of the Adenosine Kinase Gene during Early Postnatal Brain Development and Maturation.Frontiers in molecular neuroscience · 2016Article
- Direct or indirect stimulation of adenosine A2A receptors enhances bone regeneration as well as bone morphogenetic protein-2.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- The oncogenic properties of EWS/WT1 of desmoplastic small round cell tumors are unmasked by loss of p53 in murine embryonic fibroblasts.BMC cancer · 2013Article
- Dipyridamole analogs as pharmacological inhibitors of equilibrative nucleoside transporters. Identification of novel potent and selective inhibitors of the adenosine transporter function of human equilibrative nucleoside transporter 4 (hENT4).Biochemical pharmacology · 2013Article
- Cigarette smoke component acrolein modulates chromatin assembly by inhibiting histone acetylation.The Journal of biological chemistry · 2013Article
- Ewing sarcoma/peripheral primitive neuroectodermal tumor and related tumors.Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society · 2012Review
- A rapidly developing lung mass diagnosed as desmoplastic small round cell tumor.Lung India : official organ of Indian Chest Society · 2011Article
- [Cystic desmoplastic small round cell tumor: tumor development from cystic-"mesothelioblastic" areas?].Der Pathologe · 2010Article
- Soft tissue tumors associated with EWSR1 translocation.Virchows Archiv : an international journal of pathology · 2010Review
- EWS/FLI1 oncogene activates caspase 3 transcription and triggers apoptosis in vivo.Cancer research · 2010Article
- Podocyte-specific expression of organic cation transporter PMAT: implication in puromycin aminonucleoside nephrotoxicity.American journal of physiology. Renal physiology · 2009Article
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Authors and funding
8 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundDesmoplastic Small Round Cell Tumor (DSRCT) is a highly aggressive malignancy that affects mainly adolescents and young adults. A defining characteristic of DSRCT is a specific chromosomal translocation, t(11;22)(p13;q12), that fuses EWS with WT1, leading to a production of two isoforms of chimeric transcription factor, EWS/WT1(-KTS) and EWS/WT1(+KTS). The chimeric proteins are thought to play critical roles in various stages of oncogenesis through aberrant transcription of different genes, but only a few of these genes have been identified. METHODOLOGY/PRINCIPAL
findingsWe report the identification of a new target of EWS/WT1, ENT4 (equilibrative nucleoside transporter 4) which encodes a pH-dependent adenosine transporter. ENT4 is transcriptionally activated by both isoforms of EWS/WT1 as evidenced by promoter-reporter and chromatin immunoprecipitation (ChIP) analyses. Furthermore, ENT4 is highly and specifically expressed in primary tumors of DSRCT as well as in a DSRCT cell line, JN-DSRCT-1. Treatment of JN-DSRCT-1 cells with adenosine analogs, such as 2-chloro-2'-deoxyadenosine (2-CdA), resulted in an increased cytotoxic response in dose- and pH-dependent manner. CONCLUSIONS/SIGNIFICANCE: Our detailed analyses of a novel target of EWS/WT1 in DSRCT reveal an insight into the oncogenic mechanism of EWS-fusion chromosomal translocation gene products and provide a new marker for DSRCT. Furthermore, identification of ENT4 as a highly expressed transcript in DSRCT may represent an attractive pathway for targeting chemotherapeutic drugs into DSRCT.
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