ArticleJournal of immunology (Baltimore, Md. : 1950)2008
Spontaneous development of a pancreatic exocrine disease in CD28-deficient NOD mice.
Article in Journal of immunology (Baltimore, Md. : 1950), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 46 citations in OpenAlex.
- PD-1/PDL1 Blockade Exacerbates Pancreatic Damage and Immune Response in a Mouse Model of Acute Pancreatitis.Inflammation · 2021Article
- Possible involvement of autoimmunity in fulminant type 1 diabetes.Diabetology international · 2020Review
- Article
- NOD mice, susceptible to pancreatic autoimmunity, demonstrate delayed growth of pancreatic cancer.Oncotarget · 2017Article
- Aire-deficient mice provide a model of corneal and lacrimal gland neuropathy in Sjögren's syndrome.PloS one · 2017Article
- Impact of Immune-Modulatory Drugs on Regulatory T Cell.Transplantation · 2016Review
- New Murine Model of Early Onset Autoimmune Thyroid Disease/Hypothyroidism and Autoimmune Exocrinopathy of the Salivary Gland.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Possible involvement of Toll-like receptor 7 in the development of type 1 autoimmune pancreatitis.Journal of gastroenterology · 2015Article
- Exploiting apoptosis for therapeutic tolerance induction.Journal of immunology (Baltimore, Md. : 1950) · 2013Review
- Reduced effectiveness of CD4+Foxp3+ regulatory T cells in CD28-deficient NOD.H-2h4 mice leads to increased severity of spontaneous autoimmune thyroiditis.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Animal models of pancreatitis: can it be translated to human pain study?World journal of gastroenterology · 2013Review
- Regulatory T-cell therapy in transplantation: moving to the clinic.Cold Spring Harbor perspectives in medicine · 2013Review
- The B7-independent isoform of CTLA-4 functions to regulate autoimmune diabetes.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Nuclear export of histone deacetylase 7 during thymic selection is required for immune self-tolerance.The EMBO journal · 2012Article
- Breakdown in peripheral tolerance in type 1 diabetes in mice and humans.Cold Spring Harbor perspectives in medicine · 2012Review
- Autoantibodies in autoimmune pancreatitis.International journal of rheumatology · 2012Article
- Commensal Flora, is it an Unwelcomed Companion as a Triggering Factor of Autoimmune Pancreatitis?Frontiers in physiology · 2012Article
- Article
- Are dysregulated inflammatory responses to commensal bacteria involved in the pathogenesis of hepatobiliary-pancreatic autoimmune disease? An analysis using mice models of primary biliary cirrhosis and autoimmune pancreatitis.ISRN gastroenterology · 2011Article
- A critical role for regulatory T cell-mediated control of inflammation in the absence of commensal microbiota.The Journal of experimental medicine · 2010Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Autoimmune pancreatitis (AIP) is a heterogeneous autoimmune disease in humans characterized by a progressive lymphocytic and plasmacytic infiltrate in the exocrine pancreas. In this study, we report that regulatory T cell-deficient NOD.CD28KO mice spontaneously develop AIP that closely resembles the human disease. NOD mouse AIP was associated with severe periductal and parenchymal inflammation of the exocrine pancreas by CD4(+) T cells, CD8(+) T cells, and B cells. Spleen CD4(+) T cells were found to be both necessary and sufficient for the development of AIP. Autoantibodies and autoreactive T cells from affected mice recognized a approximately 50-kDa protein identified as pancreatic amylase. Importantly, administration of tolerogenic amylase-coupled fixed spleen cells significantly ameliorated disease severity, suggesting that this protein functions as a key autoantigen. The establishment and characterization of this spontaneous pancreatic amylase-specific AIP in regulatory T cell-deficient NOD.CD28KO mice provides an excellent model for the study of disease pathogenesis and development of new therapies for human autoimmune pancreatitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.