ArticleCell metabolism2008
Serotonin regulates C. elegans fat and feeding through independent molecular mechanisms.
Article in Cell metabolism, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers.
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Who cites it
123 citing papers in PubMed.
- Article
- Fatty acid regulation of feeding inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Unlocking neuronal health: leveraging C. elegans for drug repurposing studies.Cell communication and signaling : CCS · 2026Review
- Amitriptyline increases food intake via prdx-2 without altering other physiological parameters in C. elegans under a modified bacterial diet.Scientific reports · 2025Article
- Article
- Serotonin signaling to regulate energy metabolism: a gut microbiota perspective.Life metabolism · 2025Review
- Serotonin deficiency from constitutive SKN-1 activation drives pathogen apathy.Nature communications · 2024Article
- A homeostatic gut-to-brain insulin antagonist restrains neuronally stimulated fat loss.Nature communications · 2024Article
- Peripheral peroxisomal β-oxidation engages neuronal serotonin signaling to drive stress-induced aversive memory in C. elegans.Cell reports · 2024Article
- Mitochondrial energy state controls AMPK-mediated foraging behavior inScience advances · 2024Article
- Early exposure to a systemic stressor confers protection later in life.Nature aging · 2024Article
- A cGAL-UAS bipartite expression toolkit forProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Characterization of a novel RNAi yeast insecticide that silences mosquito 5-HT1 receptor genes.Scientific reports · 2023Article
- Chemical cognition: chemoconnectomics and convergent evolution of integrative systems in animals.Animal cognition · 2023Article
- Article
- Inter-tissue communication of mitochondrial stress and metabolic health.Life metabolism · 2023Article
- Parallel pathways for serotonin biosynthesis and metabolism in C. elegans.Nature chemical biology · 2023Article
- Application ofInternational journal of molecular sciences · 2023Review
- Article
- Diverse states and stimuli tune olfactory receptor expression levels to modulate food-seeking behavior.eLife · 2022Article
63 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
We investigated serotonin signaling in C. elegans as a paradigm for neural regulation of energy balance and found that serotonergic regulation of fat is molecularly distinct from feeding regulation. Serotonergic feeding regulation is mediated by receptors whose functions are not required for fat regulation. Serotonergic fat regulation is dependent on a neurally expressed channel and a G protein-coupled receptor that initiate signaling cascades that ultimately promote lipid breakdown at peripheral sites of fat storage. In turn, intermediates of lipid metabolism generated in the periphery modulate feeding behavior. These findings suggest that, as in mammals, C. elegans feeding behavior is regulated by extrinsic and intrinsic cues. Moreover, obesity and thinness are not solely determined by feeding behavior. Rather, feeding behavior and fat metabolism are coordinated but independent responses of the nervous system to the perception of nutrient availability.
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