ArticleBMC genomics2008
Transcriptome profiling of developmental and xenobiotic responses in a keystone soil animal, the oligochaete annelid Lumbricus rubellus.
Article in BMC genomics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 103 citations in OpenAlex.
- Animal degradation of microbial storage polyhydroxyalkanoates.Nature ecology & evolution · 2026Article
- Exploring the missing link between soil total antioxidant capacity and herbicide-induced stress on the earthworm Eudrilus eugeniae (Kinberg).Environmental science and pollution research international · 2022Review
- Insights from the proteome profile ofPeerJ · 2019Article
- Annotation of nerve cord transcriptome in earthwormGenomics data · 2017Article
- Earthworm Lumbricus rubellus MT-2: Metal Binding and Protein Folding of a True Cadmium-MT.International journal of molecular sciences · 2016Article
- Metallothionein gene activation in the earthworm (Lumbricus rubellus).Biochemical and biophysical research communications · 2015Article
- Evolutionary concepts in ecotoxicology: tracing the genetic background of differential cadmium sensitivities in invertebrate lineages.Ecotoxicology (London, England) · 2013Review
- Article
- Comparative description of ten transcriptomes of newly sequenced invertebrates and efficiency estimation of genomic sampling in non-model taxa.Frontiers in zoology · 2012Article
- Gene expression analysis of CL-20-induced reversible neurotoxicity reveals GABA(A) receptors as potential targets in the earthworm Eisenia fetida.Environmental science & technology · 2012Article
- Enchytraeus albidus microarray: enrichment, design, annotation and database (EnchyBASE).PloS one · 2012Article
- Differential gene expression analysis in Enchytraeus albidus exposed to natural and chemical stressors at different exposure periods.Ecotoxicology (London, England) · 2012Article
- Article
- Functional environmental genomics of a municipal landfill soil.Frontiers in genetics · 2012Article
- Transcriptional responses underlying the hormetic and detrimental effects of the plant secondary metabolite gossypol on the generalist herbivore Helicoverpa armigera.BMC genomics · 2011Article
- Application of physiologically based modelling and transcriptomics to probe the systems toxicology of aldicarb for Caenorhabditis elegans (Maupas 1900).Ecotoxicology (London, England) · 2011Article
- Design, validation and annotation of transcriptome-wide oligonucleotide probes for the oligochaete annelid Eisenia fetida.PloS one · 2010Article
- Transcriptome response to pollutants and insecticides in the dengue vector Aedes aegypti using next-generation sequencing technology.BMC genomics · 2010Article
- Linking toxicant physiological mode of action with induced gene expression changes in Caenorhabditis elegans.BMC systems biology · 2010Article
- Functional assessment of time course microarray data.BMC bioinformatics · 2009Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNatural contamination and anthropogenic pollution of soils are likely to be major determinants of functioning and survival of keystone invertebrate taxa. Soil animals will have both evolutionary adaptation and genetically programmed responses to these toxic chemicals, but mechanistic understanding of such is sparse. The clitellate annelid Lumbricus rubellus is a model organism for soil health testing, but genetic data have been lacking.
resultsWe generated a 17,000 sequence expressed sequence tag dataset, defining ~8,100 different putative genes, and built an 8,000-element transcriptome microarray for L. rubellus. Strikingly, less than half the putative genes (43%) were assigned annotations from the gene ontology (GO) system; this reflects the phylogenetic uniqueness of earthworms compared to the well-annotated model animals. The microarray was used to identify adult- and juvenile-specific transcript profiles in untreated animals and to determine dose-response transcription profiles following exposure to three xenobiotics from different chemical classes: inorganic (the metal cadmium), organic (the polycyclic aromatic hydrocarbon fluoranthene), and agrochemical (the herbicide atrazine). Analysis of these profiles revealed compound-specific fingerprints which identify the molecular responses of this annelid to each contaminant. The data and analyses are available in an integrated database, LumbriBASE.
conclusionL. rubellus has a complex response to contaminant exposure, but this can be efficiently analysed using molecular methods, revealing unique response profiles for different classes of effector. These profiles may assist in the development of novel monitoring or bioremediation protocols, as well as in understanding the ecosystem effects of exposure.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.