ReviewEpilepsia2008
Neurogenesis and epilepsy in the developing brain.
Review in Epilepsia, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Hippocampal Development and Epilepsy: Insights from Organoid Models.Brain sciences · 2025Review
- Genomic structural equation modeling of impulsivity and risk-taking traits reveals three latent factors distinctly associated with brain structure and development.bioRxiv : the preprint server for biology · 2025Article
- Developmental mechanisms underlying pediatric epilepsy.Frontiers in neurology · 2025Review
- Development and validation of a nomogram for the early prediction of drug resistance in children with epilepsy.Frontiers in pediatrics · 2022Article
- Sex Differences in the Epilepsies and Associated Comorbidities: Implications for Use and Development of Pharmacotherapies.Pharmacological reviews · 2020Review
- Effect of acute pentylenetetrazol injection induced epileptic seizures on rat dentate gyrus at different postnatal ages.Anatomy & cell biology · 2020Article
- Understanding the Real State of Human Adult Hippocampal Neurogenesis From Studies of Rodents and Non-human Primates.Frontiers in neuroscience · 2020Review
- Long-Term Effects of Early Life Seizures on Endogenous Local Network Activity of the Mouse Neocortex.Frontiers in synaptic neuroscience · 2018Article
- Neonatal seizures triple the risk of a remote seizure after perinatal ischemic stroke.Neurology · 2016Article
- Suppression of adult neurogenesis increases the acute effects of kainic acid.Experimental neurology · 2015Article
- Seizure evoked regulation of LIM-HD genes and co-factors in the postnatal and adult hippocampus.F1000Research · 2013Article
- Article
- Neonatal seizures: controversies and challenges in translating new therapies from the lab to the isolette.The European journal of neuroscience · 2012Review
- The effect of PTZ-induced epileptic seizures on hippocampal expression of PSA-NCAM in offspring born to kindled rats.Journal of biomedical science · 2012Article
- Enhanced integration of newborn neurons after neonatal insults.Frontiers in neuroscience · 2011Article
- Morphometrical study of polysialylated neural cell adhesion molecule positive cells in rat pups hippocampus following induction of seizure during pregnancy.Iranian biomedical journal · 2011Article
- Interictal spikes in developing rats cause long-standing cognitive deficits.Neurobiology of disease · 2010Article
- Postnatal neurogenesis as a therapeutic target in temporal lobe epilepsy.Epilepsy research · 2009Review
- Adult neurogenesis, mental health, and mental illness: hope or hype?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Review
- Epilepsy and the plastic mind.Epilepsy currentsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Multiple studies have highlighted how seizures induce different molecular, cellular, and physiologic consequences in an immature brain as compared to a mature brain. In keeping with these studies, seizures early in life alter dentate granule cell birth in different, and even opposing, fashion to adult seizure models (see Table 1). During the first week of rodent postnatal life, seizures decrease cell birth in the postictal period, but do not alter the maturation of newborn cells. Seizures during the second week of life have varied effects on dentate granule cell birth, either causing no change or increasing birth, and may promote a mild increase in neuronal survival. During the third and fourth weeks of life, seizures begin to increase cell birth similar to that seen in adult seizure models. Interestingly, animals that experienced seizure during the first month of life have an increase in cell birth during adulthood, opposite to the reported decrease in chronic animals experiencing a prolonged seizure as an adult. Children have more ongoing cell birth in the dentate gyrus than adults, and markers of cell division are further increased in children with refractory temporal lobe epilepsy. There are clear age-dependent differences in how seizures alter cell birth in the dentate gyrus both acutely and chronically. Future studies need to focus on how these changes in neurogenesis influence dentate gyrus function and what they imply for epileptogenesis and learning and memory impairments, so commonly found in children with temporal lobe epilepsy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.