ArticleThe Journal of infectious diseases2008
Neutralization of multiple staphylococcal superantigens by a single-chain protein consisting of affinity-matured, variable domain repeats.
Article in The Journal of infectious diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Sepsis: mechanisms of bacterial injury to the patient.Scandinavian journal of trauma, resuscitation and emergency medicine · 2019Review
- Review
- Toxins as biological weapons for terror-characteristics, challenges and medical countermeasures: a mini-review.Disaster and military medicine · 2016Review
- Review
- Staphylococcal Enterotoxin B-specific monoclonal antibody 20B1 successfully treats diverse Staphylococcus aureus infections.The Journal of infectious diseases · 2013Article
- Staphylococcal and streptococcal superantigen exotoxins.Clinical microbiology reviews · 2013Review
- Atopic dermatitis: a disease of altered skin barrier and immune dysregulation.Immunological reviews · 2011Review
- Generation and characterization of high affinity human monoclonal antibodies that neutralize staphylococcal enterotoxin B.Journal of immune based therapies and vaccines · 2010Article
- New insights into the prevention of staphylococcal infections and toxic shock syndrome.Expert review of clinical pharmacology · 2010Article
- Staphylococcal enterotoxins.Toxins · 2010Review
- Toxins from bacteria.EXS · 2010Review
- Recent insights into atopic dermatitis and implications for management of infectious complications.The Journal of allergy and clinical immunology · 2010Review
- Attenuation of massive cytokine response to the staphylococcal enterotoxin B superantigen by the innate immunomodulatory protein lactoferrin.Clinical and experimental immunology · 2009Article
- Progress towards recombinant anti-infective antibodies.Recent patents on anti-infective drug discovery · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Staphylococcus aureus secretes various toxins that act as superantigens by stimulating a large fraction of the host's T cells. Toxin binding to variable domains of T cell receptor beta chains (Vbeta) leads to massive release of inflammatory molecules and potentially to toxic shock syndrome (TSS). Previously, we generated soluble forms of different Vbeta domains with a high affinity for binding superantigens. However, a broader spectrum antagonist is required for the neutralization of multiple toxins. In the present study, we expressed Vbeta domains in tandem as a single-chain protein and neutralized the clinically important superantigens staphylococcal enterotoxin B and TSS toxin-1 with a single agent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.