ReviewMolecular neurobiology
Neurosteroids in the Purkinje cell: biosynthesis, mode of action and functional significance.
Review in Molecular neurobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 76 citations in OpenAlex.
- Biochemical characterization of zebrafish Paqr5b.Biochemistry and biophysics reports · 2025Article
- Membrane progesterone receptor γ (paqr5b) is essential for the formation of neurons in the zebrafish olfactory rosette.Scientific reports · 2024Article
- Neuroactive Steroids, Toll-like Receptors, and Neuroimmune Regulation: Insights into Their Impact on Neuropsychiatric Disorders.Life (Basel, Switzerland) · 2024Review
- De Novo Synthesized Estradiol: A Role in Modulating the Cerebellar Function.International journal of molecular sciences · 2020Review
- Neuroprotective actions of cerebellar and pineal allopregnanolone on Purkinje cells.FASEB bioAdvances · 2020Review
- Sexually dimorphic leanness and hypermobility in p16Scientific reports · 2019Article
- Ablation of glucocorticoid receptor in the hindbrain of the mouse provides a novel model to investigate stress disorders.Scientific reports · 2019Article
- Mitochondria- and Oxidative Stress-Targeting Substances in Cognitive Decline-Related Disorders: From Molecular Mechanisms to Clinical Evidence.Oxidative medicine and cellular longevity · 2019Review
- Hormonal Changes Associated With Intra-Uterine Growth Restriction: Impact on the Developing Brain and Future Neurodevelopment.Frontiers in endocrinology · 2019Review
- STARD6 on steroids: solution structure, multiple timescale backbone dynamics and ligand binding mechanism.Scientific reports · 2016Article
- Neurosteroids are reduced in diabetic neuropathy and may be associated with the development of neuropathic pain.F1000Research · 2016Article
- 7α-Hydroxypregnenolone, a key neuronal modulator of locomotion, stimulates upstream migration by means of the dopaminergic system in salmon.Scientific reports · 2015Article
- Developmentally regulated neurosteroid synthesis enhances GABAergic neurotransmission in mouse thalamocortical neurones.The Journal of physiology · 2015Article
- GABAA receptor-mediated tonic depolarization in developing neural circuits.Molecular neurobiology · 2014Review
- Biosynthesis and biological action of pineal allopregnanolone.Frontiers in cellular neuroscience · 2014Review
- Possible role of pineal allopregnanolone in Purkinje cell survival.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- The cerebellum as a target for estrogen action.Frontiers in neuroendocrinology · 2012Review
- Location, location, location: genetic regulation of neural sex differences.Reviews in endocrine & metabolic disorders · 2012Review
- Alzheimer's disease, oestrogen and mitochondria: an ambiguous relationship.Molecular neurobiology · 2012Review
- Neurosteroid biosynthesis and action during cerebellar development.Cerebellum (London, England) · 2012Review
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurosteroids are synthesized de novo from cholesterol in the brain. To understand neurosteroid action in the brain, data on the regio- and temporal-specific synthesis of neurosteroids are needed. Recently the Purkinje cell, an important cerebellar neuron, has been identified as a major site for neurosteroid formation in vertebrates. This is the first demonstration of de novo neuronal neurosteroidogenesis in the brain. Since this discovery, organizing actions of neurosteroids are becoming clear by the studies using the Purkinje cell as an excellent cellular model. In mammals, the Purkinje cell actively synthesizes progesterone and estradiol de novo from cholesterol during neonatal life. Both progesterone and estradiol promote dendritic growth, spinogenesis, and synaptogenesis via each cognate nuclear receptor in the developing Purkinje cell. Such organizing actions that may be mediated by neurotrophic factors, such as brain-derived neurotrophic factor (BDNF), contribute to the formation of cerebellar neuronal circuit during neonatal life. Allopregnanolone, a progesterone metabolite, is also synthesized in the cerebellum and acts on Purkinje cell survival in the neonate. This review summarizes the advances made in our understanding of the biosynthesis, mode of action and functional significance of neurosteroids in the Purkinje cell.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.