ReviewJournal of molecular medicine (Berlin, Germany)2008
Deconstructing human embryonic stem cell cultures: niche regulation of self-renewal and pluripotency.
Review in Journal of molecular medicine (Berlin, Germany), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Niche-Mediated Neural Priming Enables Robust and Scalable Generation of Human Choroid Plexus Organoids.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Three-dimensional bioprinting of functional β-islet-like constructs.International journal of bioprinting · 2023Article
- Photobiomodulation: An Effective Approach to Enhance Proliferation and Differentiation of Adipose-Derived Stem Cells into Osteoblasts.Stem cells international · 2021Review
- Zinc Maintains Embryonic Stem Cell Pluripotency and Multilineage Differentiation Potential via AKT Activation.Frontiers in cell and developmental biology · 2019Article
- Neurotrophin Signaling and Stem Cells-Implications for Neurodegenerative Diseases and Stem Cell Therapy.Molecular neurobiology · 2017Review
- The Roles of Insulin-Like Growth Factors in Mesenchymal Stem Cell Niche.Stem cells international · 2017Review
- Reversible lineage-specific priming of human embryonic stem cells can be exploited to optimize the yield of differentiated cells.Stem cells (Dayton, Ohio) · 2015Article
- Spontaneously differentiated GATA6-positive human embryonic stem cells represent an important cellular step in human embryonic development; they are not just an artifact of in vitro culture.Stem cells and development · 2013Article
- A method for cell type marker discovery by high-throughput gene expression analysis of mixed cell populations.BMC biotechnology · 2013Article
- Embryonic and induced pluripotent stem cells: understanding, creating, and exploiting the nano-niche for regenerative medicine.ACS nano · 2013Review
- A novel platform to enable the high-throughput derivation and characterization of feeder-free human iPSCs.Scientific reports · 2012Article
- A synthetic, xeno-free peptide surface for expansion and directed differentiation of human induced pluripotent stem cells.PloS one · 2012Article
- Developing defined culture systems for human pluripotent stem cells.Regenerative medicine · 2011Review
- Clonal interrogation of stem cells.Nature methods · 2011Review
- Article
- Embryonic stem cell application in drug discovery.Acta pharmacologica Sinica · 2011Review
- An optimized small molecule inhibitor cocktail supports long-term maintenance of human embryonic stem cells.Nature communications · 2011Article
- Endoplasmic reticulum stress signals in defined human embryonic stem cell lines and culture conditions.Stem cell reviews and reports · 2010Article
- Random mitotic activities across human embryonic stem cell colonies.Stem cells and development · 2010Article
- Culture of human pluripotent stem cells using completely defined conditions on a recombinant E-cadherin substratum.BMC developmental biology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The factors and signaling pathways controlling pluripotent human cell properties, both embryonic and induced, have not been fully investigated. Failure to account for functional heterogeneity within human embryonic stem cell (hESC) cultures has led to inconclusive results in previous work examining extrinsic influences governing hESC fate (self renewal vs. differentiation vs. death). Here, we attempt to reconcile these inconsistencies with recent reports demonstrating that an autologously produced in vitro niche regulates hESCs. Moreover, we focus on the reciprocal paracrine signals within the in vitro hESC niche allowing for the maintenance and/or expansion of the hESC colony-initiating cell (CIC). Based on this, it is clear that separation of hESC-CICs, apart from their differentiated derivatives, will be essential in future studies involving their molecular regulation. Understanding how extrinsic factors control hESC self-renewal and differentiation will allow us to culture and differentiate these pluripotent cells with higher efficiency. This knowledge will be essential for clinical applications using human pluripotent cells in regenerative medicine.
Indexed as
Identifiers
18521556What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.