ArticleMolecular oncology2007
Green tea catechins suppress the DNA synthesis marker MCM7 in the TRAMP model of prostate cancer.
Article in Molecular oncology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Green Tea Epigallocatechin-3-Gallate Regulates Autophagy in Male and Female Reproductive Cancer.Frontiers in pharmacology · 2022Review
- Anti-Cancer Effects of Green Tea Polyphenols Against Prostate Cancer.Molecules (Basel, Switzerland) · 2019Review
- Kinetics and Mechanistic Studies on the Reaction between Cytochrome c and Tea Catechins.Antioxidants (Basel, Switzerland) · 2014Article
- Safety and chemopreventive effect of Polyphenon E in preventing early and metastatic progression of prostate cancer in TRAMP mice.Cancer prevention research (Philadelphia, Pa.) · 2014Article
- New insights into the mechanisms of green tea catechins in the chemoprevention of prostate cancer.Nutrition and cancer · 2012Review
- Anticancer activity of green tea polyphenols in prostate gland.Oxidative medicine and cellular longevity · 2012Review
- Chemopreventive effects of tea in prostate cancer: green tea versus black tea.Molecular nutrition & food research · 2011Review
- Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation.Science signaling · 2010Article
- Green tea polyphenols for prostate cancer chemoprevention: a translational perspective.Phytomedicine : international journal of phytotherapy and phytopharmacology · 2010Review
- Lack of evidence for green tea polyphenols as DNA methylation inhibitors in murine prostate.Cancer prevention research (Philadelphia, Pa.) · 2009Article
- Effective prostate cancer chemopreventive intervention with green tea polyphenols in the TRAMP model depends on the stage of the disease.Clinical cancer research : an official journal of the American Association for Cancer Research · 2009Article
- Review: green tea polyphenols in chemoprevention of prostate cancer: preclinical and clinical studies.Nutrition and cancer · 2009Review
- Green tea catechins suppress the DNA synthesis marker MCM7 in the TRAMP model of prostate cancer.Molecular oncology · 2007Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Green tea catechins (GTCs) exert chemopreventive effects in many cancer models. Several studies implicate the DNA synthesis marker minichromosome maintenance protein 7 (MCM7) in prostate cancer progression, growth and invasion; representing a novel therapeutic target. In this study, we investigated the effect of GTCs on MCM7 expression in the transgenic adenocarcinoma mouse prostate model (TRAMP). DNA microarray, immunohistochemistry and western blot analysis showed that GTCs significantly suppressed MCM7 in the TRAMP mice treated with GTCs. Our study indicates that the cellular DNA replication factor MCM7 is involved in prostate cancer (CaP) and MCM7 gene expression was reduced by GTCs. Together, these results suggest a possible role of GTCs in CaP chemoprevention in which MCM7 plays a critical role.
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Registered trials
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