ArticleClinical cancer research : an official journal of the American Association for Cancer Research2008
Protein expression of platelet-derived growth factor receptor correlates with malignant histology and PTEN with survival in childhood gliomas.
Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 79 citations in OpenAlex.
- Immunohistochemical Expression of PTEN in Canine Gliomas.Animals : an open access journal from MDPI · 2024Article
- Deciphering Glioblastoma: Fundamental and Novel Insights into the Biology and Therapeutic Strategies of Gliomas.Current issues in molecular biology · 2024Review
- Overexpression of mTOR and p(240-244)S6 in IDH1 Wild-Type Human Glioblastomas Is Predictive of Low Survival.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2018Article
- miR-141-3p is a key negative regulator of the EGFR pathway in osteosarcoma.OncoTargets and therapy · 2018Article
- Characterization of the transcriptional and metabolic responses of pediatric high grade gliomas to mTOR-HIF-1α axis inhibition.Oncotarget · 2017Article
- Pediatric high-grade glioma: current molecular landscape and therapeutic approaches.Journal of neuro-oncology · 2017Review
- Evaluation of Akt and RICTOR Expression Levels in Astrocytomas of All Grades.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2017Article
- Review
- A phase I study of single-agent perifosine for recurrent or refractory pediatric CNS and solid tumors.PloS one · 2017Article
- MicroRNA-1908 functions as a glioblastoma oncogene by suppressing PTEN tumor suppressor pathway.Molecular cancer · 2015Article
- A preclinical study demonstrating the efficacy of nilotinib in inhibiting the growth of pediatric high-grade glioma.Journal of neuro-oncology · 2015Article
- Inhibition of Pediatric Glioblastoma Tumor Growth by the Anti-Cancer Agent OKN-007 in Orthotopic Mouse Xenografts.PloS one · 2015Article
- Angiogenesis and angiogenic tyrosine kinase receptor expression in pediatric brain tumors.Pathology oncology research : POR · 2014Article
- Peptide arrays for development of PDGFRβ Affine molecules.Molecular imaging and biology · 2013Article
- The p53-microRNA-34a axis regulates cellular entry receptors for tumor-associated human herpes viruses.Medical hypotheses · 2013Article
- PTEN promoter methylation and activation of the PI3K/Akt/mTOR pathway in pediatric gliomas and influence on clinical outcome.Neuro-oncology · 2012Article
- Platelet-derived growth factor receptors differentially inform intertumoral and intratumoral heterogeneity.Genes & development · 2012Article
- Paediatric and adult malignant glioma: close relatives or distant cousins?Nature reviews. Clinical oncology · 2012Review
- Impact of molecular biology studies on the understanding of brain tumors in childhood.Current oncology reports · 2012Article
- Temozolomide for pediatric high-grade gliomas.Current neurology and neuroscience reports · 2012Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
purposeWe previously showed that overexpression of epidermal growth factor receptor (EGFR) is associated with malignant grade in childhood glioma. The objective of this study was to determine whether protein expression of EGFR or platelet-derived growth factor receptor (PDGFR) and their active signaling pathways are related to malignant histology, progression of disease, and worse survival. EXPERIMENTAL
designTissue microarrays were prepared from untreated tumors from 85 new glioma patients [22 high-grade gliomas (HGG) and 63 low-grade gliomas (LGG)] diagnosed at this institution from 1989 to 2004. Immunohistochemistry was used to assess total expression of EGFR, PDGFR beta, and PTEN and expression of phosphorylated EGFR, phosphorylated PDGFR alpha (p-PDGFR alpha), phosphorylated AKT, phosphorylated mitogen-activated protein kinase, and phosphorylated mammalian target of rapamycin. These results were correlated with clinicopathologic data, including extent of initial tumor resection, evidence of dissemination, tumor grade, proliferation index, and survival, as well as with Affymetrix gene expression profiles previously obtained from a subset of these tumors.
resultsHigh expression of p-PDGFR alpha, EGFR, PDGFR beta, and phosphorylated EGFR was seen in 85.7%, 80.0%, 78.9%, and 47.4% of HGG and 40.0%, 87.1%, 41.7%, and 30.6% of LGG, respectively. However, high expression of p-PDGFR alpha and PDGFR beta was the only significant association with malignant histology (P = 0.031 and 0.005, respectively); only the loss of PTEN expression was associated with worse overall survival. None of these targets, either alone or in combination, was significantly associated with progression-free survival in either LGG or HGG.
conclusionsHigh PDGFR protein expression is significantly associated with malignant histology in pediatric gliomas, but it does not represent an independent prognostic factor. Deficient PTEN expression is associated with worse overall survival in HGG.
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