ArticleThe Journal of cell biology2008
Piccolo modulation of Synapsin1a dynamics regulates synaptic vesicle exocytosis.
Article in The Journal of cell biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 156 citations in OpenAlex.
- Disruption of Synaptic Vesicle Trafficking in Alzheimer's and Parkinson's Disease: Mechanisms and Therapeutic Implication.International journal of molecular sciences · 2026Review
- Temporal control of eating and body weight by GHSR-expressing suprachiasmatic nucleus neurons.Cell reports · 2025Article
- Prefrontal cortex astrocytes modulate distinct neuronal populations to control anxiety-like behavior.Nature communications · 2025Article
- Piccolino is required for ribbon architecture at cochlear inner hair cell synapses and for hearing.EMBO reports · 2023Article
- Axonal transport of Hrs is activity dependent and facilitates synaptic vesicle protein degradation.Life science alliance · 2022Article
- No symphony without bassoon and piccolo: changes in synaptic active zone proteins in Huntington's disease.Acta neuropathologica communications · 2020Article
- Identification of Potential Interacting Proteins With the Extracellular Loops of the Neuronal Glycoprotein M6a by TMT/MS.Frontiers in synaptic neuroscience · 2020Article
- Article
- VAP-SCRN1 interaction regulates dynamic endoplasmic reticulum remodeling and presynaptic function.The EMBO journal · 2019Article
- The Exocyst Component Exo70 Modulates Dendrite Arbor Formation, Synapse Density, and Spine Maturation in Primary Hippocampal Neurons.Molecular neurobiology · 2019Article
- Article
- Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A.Disease models & mechanisms · 2018Article
- Parkinson's disease-linked Parkin mutations impair glutamatergic signaling in hippocampal neurons.BMC biology · 2018Article
- Vertebrate Presynaptic Active Zone Assembly: a Role Accomplished by Diverse Molecular and Cellular Mechanisms.Molecular neurobiology · 2018Review
- Identification of Fluorescent Small Molecule Compounds for Synaptic Labeling by Image-Based, High-Content Screening.ACS chemical neuroscience · 2018Article
- The presynaptic scaffolding protein Piccolo organizes the readily releasable pool at the calyx of Held.The Journal of physiology · 2018Article
- Presynaptic active zones of mammalian neuromuscular junctions: Nanoarchitecture and selective impairments in aging.Neuroscience research · 2018Review
- Quintuple labeling in the electron microscope with genetically encoded enhanced horseradish peroxidase.PloS one · 2018Article
- Shank and Zinc Mediate an AMPA Receptor Subunit Switch in Developing Neurons.Frontiers in molecular neuroscience · 2018Article
- Clarinet (CLA-1), a novel active zone protein required for synaptic vesicle clustering and release.eLife · 2017Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Active zones are specialized regions of the presynaptic plasma membrane designed for the efficient and repetitive release of neurotransmitter via synaptic vesicle (SV) exocytosis. Piccolo is a high molecular weight component of the active zone that is hypothesized to participate both in active zone formation and the scaffolding of key molecules involved in SV recycling. In this study, we use interference RNAs to eliminate Piccolo expression from cultured hippocampal neurons to assess its involvement in synapse formation and function. Our data show that Piccolo is not required for glutamatergic synapse formation but does influence presynaptic function by negatively regulating SV exocytosis. Mechanistically, this regulation appears to be calmodulin kinase II-dependent and mediated through the modulation of Synapsin1a dynamics. This function is not shared by the highly homologous protein Bassoon, which indicates that Piccolo has a unique role in coupling the mobilization of SVs in the reserve pool to events within the active zone.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.