Evidence map›Paper›PMID 18519730›Full record

Trial reportAntimicrobial agents and chemotherapy2008

Effect of chemotherapy with praziquantel on the production of cytokines and morbidity associated with schistosomiasis mansoni.

P Martins-Leite, G Gazzinelli, L F Alves-Oliveira, A Gazzinelli, L C C Malaquias, R Correa-Oliveira, A Teixeira-Carvalho, A M S Silveira

Open access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Antimicrobial agents and chemotherapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 39 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Experimental infection withParasitology · 2022
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Cytokine patterns in experimental schistosomiasis mansoni infected mice treated with silymarin.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2016
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Management of variceal hemorrhage: current concepts.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

P Martins-LeiteNúcleo de Pesquisa em Imunologia, Universidade Vale do Rio Doce, Rua Israel Pinheiro, 2000, Universitário, Governador Valadares, MG 35020-220, Brazil. alda@univale.br.
G Gazzinelli
L F Alves-Oliveira
A Gazzinelli
L C C Malaquias
R Correa-Oliveira
A Teixeira-Carvalho
A M S Silveira
Universidade Vale do Rio Doce · BRFundação Oswaldo Cruz · BRUniversidade Federal de Minas Gerais · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of the present study was to test the hypothesis that treatment of schistosomiasis mansoni with praziquantel can alter significantly the immune response of patients and generate a reversal of the level of fibrosis. Peripheral blood mononuclear cell (PBMC) samples were collected from, and abdominal ultrasound examinations conducted on, volunteers infected with Schistosoma mansoni and living in an area where the disease is endemic, both prior to and one year after treatment with praziquantel. Subjects were classified into groups according to the level of pathology (i.e., absent, incipient, moderate, or severe fibrosis). PBMCs were stimulated with schistosome soluble egg antigens (SEA), and the levels of production of the cytokines gamma interferon (IFN-gamma), tumor necrosis factor alpha, transforming growth factor beta, and interleukin-4 (IL-4), IL-10, and IL-13 were determined. The chemotherapy was effective in reducing morbidity, particularly for individuals presenting with severe fibrosis. When levels of cytokine production in posttreatment PBMC cultures stimulated by SEA were categorized as low or high, significant differences in the distribution of IL-13 levels between groups presenting with or not presenting with fibrosis were established. Comparison of pre- and posttreatment SEA-induced cytokine levels in individuals who had experienced no change in the grade of fibrosis following chemotherapy revealed that the level of IFN-gamma decreased in subjects with fibrosis whereas that of IL-10 decreased in individuals with and without fibrosis. The data suggest that chemotherapy is effective in reducing the morbidity of the disease and that the level of IL-13 may be a useful indicator of the persistence of fibrosis following treatment.

Indexed as

AdolescentAdultAgedAged, 80 and overAnimalsAnthelminticsBrazilCytokinesFemaleHumansInterferon-gammaInterleukin-10Interleukin-13Interleukin-4Leukocytes, MononuclearMaleAnthelminticsCytokinesInterferon-gammaInterleukin-10Interleukin-13Interleukin-4PraziquantelTransforming Growth Factor beta

Identifiers

PMID18519730
PMCPMC2493106
OpenAlexW2167977251

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.