ArticleGenome research2008
The C. savignyi genetic map and its integration with the reference sequence facilitates insights into chordate genome evolution.
Article in Genome research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- An Improved Chromosome-Level Genome Assembly and Comprehensive Annotation of the Model Ascidian Ciona savignyi.Scientific data · 2026Article
- Tunicates have a complex, highly dynamic TNF superfamily.PloS one · 2026Article
- Dynamics of Chromatin Opening across Larval Development in the Urochordate AscidianInternational journal of molecular sciences · 2024Article
- The Genome of the "Sea Vomit"Life (Basel, Switzerland) · 2021Article
- Chromosomal Inversion Polymorphisms in Two Sympatric Ascidian Lineages.Genome biology and evolution · 2021Article
- A Nearly Complete Genome of Ciona intestinalis Type A (C. robusta) Reveals the Contribution of Inversion to Chromosomal Evolution in the Genus Ciona.Genome biology and evolution · 2019Article
- A draft genome of the striped catfish, Pangasianodon hypophthalmus, for comparative analysis of genes relevant to development and a resource for aquaculture improvement.BMC genomics · 2018Article
- Exploiting the extraordinary genetic polymorphism of ciona for developmental genetics with whole genome sequencing.Genetics · 2014Article
- Review
- Ciona genetics.Methods in molecular biology (Clifton, N.J.) · 2011Article
- Integration of the genetic map and genome assembly of fugu facilitates insights into distinct features of genome evolution in teleosts and mammals.Genome biology and evolution · 2011Article
- Large-scale analysis of orthologs and paralogs under covarion-like and constant-but-different models of amino acid evolution.Molecular biology and evolution · 2010Article
- doublesex/mab3 related-1 (dmrt1) is essential for development of anterior neural plate derivatives in Ciona.Development (Cambridge, England) · 2010Article
- miRTRAP, a computational method for the systematic identification of miRNAs from high throughput sequencing data.Genome biology · 2010Article
- Construction of a high-resolution genetic linkage map and comparative genome analysis for the reef-building coral Acropora millepora.Genome biology · 2009Article
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Authors and funding
6 authors at 5 institutions in 3 countries.
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Abstract
The urochordate Ciona savignyi is an emerging model organism for the study of chordate evolution, development, and gene regulation. The extreme level of polymorphism in its population has inspired novel approaches in genome assembly, which we here continue to develop. Specifically, we present the reconstruction of all of C. savignyi's chromosomes via the development of a comprehensive genetic map, without a physical map intermediate. The resulting genetic map is complete, having one linkage group for each one of the 14 chromosomes. Eighty-three percent of the reference genome sequence is covered. The chromosomal reconstruction allowed us to investigate the evolution of genome structure in highly polymorphic species, by comparing the genome of C. savignyi to its divergent sister species, Ciona intestinalis. Both genomes have been extensively reshaped by intrachromosomal rearrangements. Interchromosomal changes have been extremely rare. This is in striking contrast to what has been observed in vertebrates, where interchromosomal events are commonplace. These results, when considered in light of the neutral theory, suggest fundamentally different modes of evolution of animal species with large versus small population sizes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.