ArticleThe Journal of experimental medicine2008
IKKbeta/NF-kappaB and the miscreant macrophage.
Article in The Journal of experimental medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 49 citations in OpenAlex.
- Reprogramming macrophage metabolism for cardiovascular therapy: From molecular pathways to precision nanomedicine.Materials today. Bio · 2026Review
- Identification and validation of biomarkers of Shenggu Zaizao Wan in the treatment of steroid-induced osteonecrosis of the femoral head by integrating network pharmacology and bulk transcriptomic.Frontiers in medicine · 2026Article
- MED8 is related to tumor immunity and has predictive value in the prognosis and treatment of glioma.Discover oncology · 2025Article
- Precision treatment of viral pneumonia through macrophage-targeted lipid nanoparticle delivery.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Investigation into the role of the MITA-TRIM38 interaction in regulating pyroptosis and maintaining immune tolerance at the maternal-fetal interface.Cell death & disease · 2023Article
- Intranasal influenza-vectored COVID-19 vaccine restrains the SARS-CoV-2 inflammatory response in hamsters.Nature communications · 2023Article
- Gorham-Stout case report: a multi-omic analysis reveals recurrent fusions as new potential drivers of the disease.BMC medical genomics · 2022Article
- Regulatory mechanisms of B cell responses and the implication in B cell-related diseases.Journal of biomedical science · 2019Review
- TIPE2 suppresses atherosclerosis by exerting a protective effect on macrophages via the inhibition of the Akt signaling pathway.Experimental and therapeutic medicine · 2019Article
- Chemokine receptor Cxcr4 contributes to kidney fibrosis via multiple effectors.American journal of physiology. Renal physiology · 2015Article
- IKKβ in myeloid cells controls the host response to lethal and sublethal Francisella tularensis LVS infection.PloS one · 2013Article
- Endometriosis, a disease of the macrophage.Frontiers in immunology · 2013Article
- A subset of human uterine endometrial macrophages is alternatively activated.American journal of reproductive immunology (New York, N.Y. : 1989) · 2012Article
- NO is a macrophage autonomous modifier of the cytokine response to streptococcal single-stranded RNA.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Deletion of the murine scavenger receptor CD68.Journal of lipid research · 2011Article
- Truncation of the deubiquitinating domain of CYLD in myelomonocytic cells attenuates inflammatory responses.PloS one · 2011Article
- Interferons direct an effective innate response to Legionella pneumophila infection.The Journal of biological chemistry · 2009Article
- Macrophages are alternatively activated in patients with endometriosis and required for growth and vascularization of lesions in a mouse model of disease.The American journal of pathology · 2009Article
- Macrophage diversity in renal injury and repair.The Journal of clinical investigation · 2008Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Macrophage activation relies on complex intracellular signaling processes that integrate the need for rapid inflammatory responses to pathogens with the need to resolve inflammation without permanent harm to normal tissues. Patterns of aberrant macrophage activation characterize and sustain disorders of chronic inflammation, infection, and cancer. New studies now show a role for the NF-kappaB activator IKKbeta in promoting an alternative, immunosuppressive pattern of macrophage activation, which limits the cell's tumoricidal and bactericidal capacities. As cancers and pathogens may have evolved multiple mechanisms to manipulate macrophages for their own survival, is there anything we can do about it?
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.