ArticleGenes & development2008
Trans-regulation of the expression of the transcription factor MtHAP2-1 by a uORF controls root nodule development.
Article in Genes & development, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed, 124 citations in OpenAlex.
- Hormone-modulated transcription factors orchestrating the root nodule symbiosis.Frontiers in plant science · 2026Review
- Nuclear factor-Y transcription factors in crops: Biological roles, regulation, and breeding applications.Plant communications · 2025Review
- TheProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Genome-Wide Identification and Expression Pattern Analysis of Nuclear Factor Y B/C Genes inPlants (Basel, Switzerland) · 2025Article
- Rice Promoter Editing: An Efficient Genetic Improvement Strategy.Rice (New York, N.Y.) · 2024Review
- Dancing to a different tune, can we switch from chemical to biological nitrogen fixation for sustainable food security?PLoS biology · 2023Article
- Expression and Variation of the Genes Involved in Rhizobium Nodulation in Red Clover.Plants (Basel, Switzerland) · 2022Article
- Full-Length Transcriptome Sequencing Reveals Alternative Splicing and lncRNA Regulation during Nodule Development inInternational journal of molecular sciences · 2022Article
- NF-YB family transcription factors inFrontiers in microbiology · 2022Article
- Regulation of the Later Stages of Nodulation Stimulated by IPD3/CYCLOPS Transcription Factor and Cytokinin in PeaPlants (Basel, Switzerland) · 2021Article
- Understanding small ORF diversity through a comprehensive transcription feature classification.DNA research : an international journal for rapid publication of reports on genes and genomes · 2021Review
- Lotus japonicus Nuclear Factor YA1, a nodule emergence stage-specific regulator of auxin signalling.The New phytologist · 2021Article
- Transcriptome Analysis of Alternative Splicing Events Induced by Arbuscular Mycorrhizal Fungi (Plants (Basel, Switzerland) · 2020Article
- Article
- Developmental regulation of canonical and small ORF translation from mRNAs.Genome biology · 2020Article
- uORF Shuffling Fine-Tunes Gene Expression at a Deep Level of the Process.Plants (Basel, Switzerland) · 2020Review
- Comprehensive genome-wide identification of angiosperm upstream ORFs with peptide sequences conserved in various taxonomic ranges using a novel pipeline, ESUCA.BMC genomics · 2020Article
- Nodule Inception Is Not Required for Arbuscular Mycorrhizal Colonization ofPlants (Basel, Switzerland) · 2020Article
- uORFlight: a vehicle toward uORF-mediated translational regulation mechanisms in eukaryotes.Database : the journal of biological databases and curation · 2020Article
- Gene Expression in Nitrogen-Fixing Symbiotic Nodule Cells inThe Plant cell · 2020Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MtHAP2-1 is a CCAAT-binding transcription factor from the model legume Medicago truncatula. We previously showed that MtHAP2-1 expression is regulated both spatially and temporally by microRNA169. Here we present a novel regulatory mechanism controlling MtHAP2-1 expression. Alternative splicing of an intron in the MtHAP2-1 5'leader sequence (LS) becomes predominant during the development of root nodules, leading to the production of a small peptide, uORF1p. Our results indicate that binding of uORF1p to MtHAP2-1 5'LS mRNA leads to reduced accumulation of the MtHAP2-1 transcript and may contribute to spatial restriction of MtHAP2-1 expression within the nodule. We propose that miR169 and uORF1p play essential, sequential, and nonredundant roles in regulating MtHAP2-1 expression. Importantly, in contrast to previously described cis-acting uORFs, uORF1p is able to act in trans to down-regulate gene expression. Our work thus contributes to a better understanding of the action of upstream ORFs (uORFs) in the regulation of gene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.