Evidence map›Paper›PMID 18519634›Full record

ArticleGenes & development2008

Lego clocks: building a clock from parts.

Michael Brunner, Mirre J P Simons, Martha Merrow

Abstract readComment
In one paragraph

Article in Genes & development, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Evolution of time-keeping mechanisms: early emergence and adaptation to photoperiod.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Michael BrunnerUniversity of Heidelberg Biochemistry Center, 69120 Heidelberg, Germany. michael.brunner@bzh.uni-heidelberg.de
Mirre J P Simons
Martha Merrow

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A new finding opens up speculation that the molecular mechanism of circadian clocks in Synechococcus elongatus is composed of multiple oscillator systems (Kitayama and colleagues, this issue, pp. 1513-1521), as has been described in many eukaryotic clock model systems. However, an alternative intepretation is that the pacemaker mechanism-as previously suggested-lies primarily in the rate of ATP hydrolysis by the clock protein KaiC.

Indexed as

Biological ClocksBacterial ProteinsModels, BiologicalPhosphorylationSynechococcusBacterial Proteins

Identifiers

PMID18519634
PMCPMC2732415

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.