ArticleMolecular and cellular biology2008
A member of the p38 mitogen-activated protein kinase family is responsible for transcriptional induction of Dopa decarboxylase in the epidermis of Drosophila melanogaster during the innate immune response.
Article in Molecular and cellular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 59 citations in OpenAlex.
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- Exploring the Sublethal Impacts of Cu and Zn on Daphnia magna: a transcriptomic perspective.BMC genomics · 2024Article
- Dietary Curcumin Intake and Its Effects on the Transcriptome and Metabolome ofInternational journal of molecular sciences · 2024Article
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- Drosophila p38 MAPK interacts with BAG-3/starvin to regulate age-dependent protein homeostasis.Aging cell · 2021Article
- Functional conservation in genes and pathways linking ageing and immunity.Immunity & ageing : I & A · 2021Review
- Hypersensitivity of Vps33B mutant flies to non-pathogenic infections is dictated by aberrant activation of p38b MAP kinase.Traffic (Copenhagen, Denmark) · 2020Article
- Evolutionarily conserved transcription factors drive the oxidative stress response inThe Journal of experimental biology · 2020Article
- IIV-6 Inhibits NF-κB Responses inViruses · 2019Article
- Sexual Dimorphisms in Innate Immunity and Responses to Infection inFrontiers in immunology · 2019Review
- p38b and JAK-STAT signaling protect against Invertebrate iridescent virus 6 infection in Drosophila.PLoS pathogens · 2018Article
- A novel mode of induction of the humoral innate immune response inDisease models & mechanisms · 2017Article
- Structural Basis of the Substrate Specificity and Enzyme Catalysis of aFrontiers in molecular biosciences · 2017Article
- The Drosophila MAPK p38c regulates oxidative stress and lipid homeostasis in the intestine.PLoS genetics · 2014Article
- Dopamine dynamics and signaling in Drosophila: an overview of genes, drugs and behavioral paradigms.Experimental animals · 2014Review
- Independent pathways downstream of the Wnd/DLK MAPKKK regulate synaptic structure, axonal transport, and injury signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Activating transcription factor 3 regulates immune and metabolic homeostasis.Molecular and cellular biology · 2012Article
- High-resolution protein interaction map of the Drosophila melanogaster p38 mitogen-activated protein kinases reveals limited functional redundancy.Molecular and cellular biology · 2012Article
- Immune response in the barrier epithelia: lessons from the fruit fly Drosophila melanogaster.Journal of innate immunity · 2012Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drosophila innate immunity is controlled primarily by the activation of IMD (immune deficiency) or Toll signaling leading to the production of antimicrobial peptides (AMPs). IMD signaling also activates the JUN N-terminal kinase (JNK) cascade, which is responsible for immune induction of non-antimicrobial peptide immune gene transcription though the transcription factor AP-1. Transcription of the Dopa decarboxylase (Ddc) gene is induced in response to gram-negative and gram-positive septic injury, but not aseptic wounding. Transcription is induced throughout the epidermis and not specifically at the site of infection. Ddc transcripts are detectible within 2 h and remain high for several hours following infection with either gram-negative or gram-positive bacteria. Using Ddc-green fluorescent protein (GFP) reporter gene constructs, we show that a conserved consensus AP-1 binding site upstream of the Ddc transcription start site is required for induction. However, neither the Toll, IMD, nor JNK pathway is involved. Rather, Ddc transcription depends on a previously uncharacterized member of the p38 mitogen-activated protein kinase family, p38c. We propose that the involvement of DDC in a new pathway involved in Drosophila immunity increases the levels of dopamine, which is metabolized to produce reactive quinones that exert an antimicrobial effect on invading bacteria.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.