ArticlePhilosophy, ethics, and humanities in medicine : PEHM2008
The beginning of the end for chimpanzee experiments?
Article in Philosophy, ethics, and humanities in medicine : PEHM, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Should biomedical research with great apes be restricted? A systematic review of reasons.BMC medical ethics · 2021Pooled it
- Animal Pharmacokinetic/Pharmacodynamic Studies (APPS) Reporting Guidelines.European journal of drug metabolism and pharmacokinetics · 2018Guideline
- Silent mutations in coding regions of Hepatitis C virus affect patterns of HCV RNA structures and attenuate viral replication and pathogenesis.Genome biology · 2025Article
- A Metric-Based, Meta-Analytic Appraisal of Environmental Enrichment Efficacy in Captive Primates.Animals : an open access journal from MDPI · 2025Review
- Detailed mapping of the complex fiber structure and white matter pathways of the chimpanzee brain.Nature methods · 2024Article
- Going beyond established model systems of Alzheimer's disease: companion animals provide novel insights into the neurobiology of aging.Communications biology · 2023Review
- Engineering, decoding and systems-level characterization of chimpanzee cytomegalovirus.PLoS pathogens · 2022Article
- A Review of the Current Mammalian Models of Alzheimer's Disease and Challenges That Need to Be Overcome.International journal of molecular sciences · 2021Review
- In the era of rapid mRNA-based vaccines: Why is there no effective hepatitis C virus vaccine yet?World journal of hepatology · 2021Review
- Propofol infusions using a human target controlled infusion (TCI) pump in chimpanzees (Pan troglodytes).Scientific reports · 2021Article
- Animal Models Used in Hepatitis C Virus Research.International journal of molecular sciences · 2020Review
- Taming a beast: lessons from the domestication of hepatitis C virus.Current opinion in virology · 2019Review
- Humanized DRAGA mice immunized with Plasmodium falciparum sporozoites and chloroquine elicit protective pre-erythrocytic immunity.Malaria journal · 2018Article
- Potential damaging mutation in LRP5 from genome sequencing of the first reported chimpanzee with the Chiari malformation.Scientific reports · 2017Article
- Creating animal models, why not use the Chinese tree shrew (Zoological research · 2017Article
- The Three Rs of Animal Research: What they Mean for the Institutional Animal Care and Use Committee and Why.Science and engineering ethics · 2016Article
- Nonhuman Primates and Humanized Mice for Studies of HIV-1 Integrase Inhibitors: A Review.Pathogens & immunity · 2016Review
- Molecular evolution and expression profile of the chemerine encoding gene RARRES2 in baboon and chimpanzee.Biological research · 2015Article
- Humanized HLA-DR4.RagKO.IL2RγcKO.NOD (DRAG) mice sustain the complex vertebrate life cycle of Plasmodium falciparum malaria.Malaria journal · 2014Article
- Reducing the neural search space for hominid cognition: what distinguishes human and great ape brains from those of small apes?Psychonomic bulletin & review · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The advanced sensory, psychological and social abilities of chimpanzees confer upon them a profound ability to suffer when born into unnatural captive environments, or captured from the wild--as many older research chimpanzees once were--and when subsequently subjected to confinement, social disruption, and involuntary participation in potentially harmful biomedical research. Justifications for such research depend primarily on the important contributions advocates claim it has made toward medical advancements. However, a recent large-scale systematic review indicates that invasive chimpanzee experiments rarely provide benefits in excess of their profound animal welfare, bioethical and financial costs. The approval of large numbers of these experiments--particularly within the US--therefore indicates a failure of the ethics committee system. By 2008, legislative or policy bans or restrictions on invasive great ape experimentation existed in seven European countries, Japan, Australia and New Zealand. In continuing to conduct such experiments on chimpanzees and other great apes, the US was almost completely isolated internationally. In 2007, however, the US National Institutes of Health National Center for Research Resources implemented a permanent funding moratorium on chimpanzee breeding, which is expected to result in a major decline in laboratory chimpanzee numbers over the next 30 years, as most are retired or die. Additionally, in 2008, The Great Ape Protection Act was introduced to Congress. The bill proposed to end invasive research and testing on an estimated 1,200 chimpanzees confined within US laboratories, and, for approximately 600 federally-owned, to ensure their permanent retirement to sanctuaries. These events have created an unprecedented opportunity for US legislators, researchers, and others, to consider a global ban on invasive chimpanzee research. Such a ban would not only uphold the best interests of chimpanzees, and other research fields presently deprived of funding, but would also increase the compliance of US animal researchers with internationally-accepted animal welfare and bioethical standards. It could even result in the first global moratorium on invasive research, for any non-human species, unless conducted in the best interests of the individual or species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.