ArticleLangmuir : the ACS journal of surfaces and colloids2008
Cholesterol packing around lipids with saturated and unsaturated chains: a simulation study.
Article in Langmuir : the ACS journal of surfaces and colloids, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 109 citations in OpenAlex.
- Membrane composition-dependent patterning of Rho and F-actin in an artificial cell cortex.Molecular biology of the cell · 2026Article
- Impact of lipid asymmetry on membrane biophysical properties: Insights from molecular dynamics simulations.Quantitative biology (Beijing, China) · 2025Article
- Cholesterol catalyzes unfolding in membrane-inserted motifs of the pore forming protein cytolysin A.Biophysical journal · 2023Article
- Amyloid β Dodecamer Disrupts the Neuronal Membrane More Strongly than the Mature Fibril: Understanding the Role of Oligomers in Neurotoxicity.The journal of physical chemistry. B · 2022Article
- The role of size and nature in nanoparticle binding to a model lung membrane: an atomistic study.Nanoscale advances · 2021Article
- Effects of cholesterol on chlorzoxazone translocation across POPC bilayer.Journal of molecular modeling · 2021Article
- Influence of Membrane Phase on the Optical Properties of DPH.Molecules (Basel, Switzerland) · 2020Article
- The Interaction of Flavonols with Membrane Components: Potential Effect on Antioxidant Activity.The Journal of membrane biology · 2020Article
- All n-3 PUFA are not the same: MD simulations reveal differences in membrane organization for EPA, DHA and DPA.Biochimica et biophysica acta. Biomembranes · 2018Article
- Membrane Binding of HIV-1 Matrix Protein: Dependence on Bilayer Composition and Protein Lipidation.Journal of virology · 2016Article
- Effects of truncating van der Waals interactions in lipid bilayer simulations.The Journal of chemical physics · 2014Article
- Improved Coarse-Grained Modeling of Cholesterol-Containing Lipid Bilayers.Journal of chemical theory and computation · 2014Article
- The structural basis of cholesterol accessibility in membranes.Biophysical journal · 2013Article
- Cholesterol translocation in a phospholipid membrane.Biophysical journal · 2013Article
- A Simulation Study of the Self-Assembly of Coarse-Grained Skin Lipids.Soft matter · 2012Article
- Nonintercalating nanosubstrates create asymmetry between bilayer leaflets.Langmuir : the ACS journal of surfaces and colloids · 2012Article
- The toxicity of amyloid β oligomers.International journal of molecular sciences · 2012Review
- Molecular dynamics simulation of HIV fusion inhibitor T-1249: insights on peptide-lipid interaction.Computational and mathematical methods in medicine · 2012Article
- Impact of sterol tilt on membrane bending rigidity in cholesterol and 7DHC-containing DMPC membranes.Soft matter · 2011Article
- Derivatives of rhodamine 19 as mild mitochondria-targeted cationic uncouplers.The Journal of biological chemistry · 2011Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The fundamental role of cholesterol in the regulation of eukaryotic membrane structure is well-established. However the manner in which atomic level interactions between cholesterol and lipids, with varying degrees of chain unsaturation and polar groups, affect the overall structure and organization of the bilayer is only beginning to be understood. In this paper we describe a series of Molecular Dynamics simulations designed to provide new insights into lipid-cholesterol interactions as a function of chain unsaturation. We have run simulations of varying concentrations of cholesterol in dipalmitoyl phosphatidylcholine (DPPC), palmitoyl-oleyol phosphatidylcholine (POPC), and dioleyol phosphatidylcholine (DOPC) bilayers. Structural analysis of the simulations reveals both atomistic and systemic details of the interactions and are presented here. In particular, we find that the minimum partial molecular area of cholesterol occurs in POPC-Chol mixtures implying the most favorable packing. Physically, this appears to be related to the fact that the two faces of the cholesterol molecule are different from each other and that the steric cross section of cholesterol molecules drops sharply near the small chain tails.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.