ArticlePharmaceutical research2008
Injectable biodegradable polyurethane scaffolds with release of platelet-derived growth factor for tissue repair and regeneration.
Article in Pharmaceutical research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 129 citations in OpenAlex.
- Review
- Bioresorbable, wireless dual stimulator for peripheral nerve regeneration.Nature communications · 2025Article
- Synthesis of Flexible Polyamide Aerogels Cross-Linked with a Tri-Isocyanate.Gels (Basel, Switzerland) · 2024Article
- Polymeric microcarriers for minimally-invasive cell delivery.Frontiers in bioengineering and biotechnology · 2023Review
- Current Concepts and Methods in Tissue Interface Scaffold Fabrication.Biomimetics (Basel, Switzerland) · 2022Review
- Reactive oxygen species-degradable polythioketal urethane foam dressings to promote porcine skin wound repair.Science translational medicine · 2022Article
- Dendritic cell biocompatibility of ether-based urethane films.Journal of applied toxicology : JAT · 2021Article
- Characterization of Partially Covered Self-Expandable Metallic Stents for Esophageal Cancer Treatment:ACS biomaterials science & engineering · 2021Article
- Design and characterization of plasticized bacterial cellulose/waterborne polyurethane composite with antibacterial function for nasal stenting.Regenerative biomaterials · 2020Article
- Production of Biodegradable Palm Oil-Based Polyurethane as Potential Biomaterial for Biomedical Applications.Polymers · 2020Article
- Concurrent Local Delivery of Diflunisal Limits Bone Destruction but Fails To Improve Systemic Vancomycin Efficacy during Staphylococcus aureus Osteomyelitis.Antimicrobial agents and chemotherapy · 2020Article
- Boosting the Osteogenic and Angiogenic Performance of Multiscale Porous Polycaprolactone Scaffolds byACS applied materials & interfaces · 2020Article
- Poly(Thioketal Urethane) Autograft Extenders in an Intertransverse Process Model of Bone Formation.Tissue engineering. Part A · 2019Article
- Article
- Settable polymer/ceramic composite bone grafts stabilize weight-bearing tibial plateau slot defects and integrate with host bone in an ovine model.Biomaterials · 2018Article
- Sustained Release Drug Delivery Applications of Polyurethanes.Pharmaceutics · 2018Review
- Biomimetic polyurethane/TiOMaterials science & engineering. C, Materials for biological applications · 2018Article
- Resorbable Nanocomposites with Bone-Like Strength and Enhanced Cellular Activity.Journal of materials chemistry. B · 2017Article
- Alternating air-medium exposure in rotating bioreactors optimizes cell metabolism in 3D novel tubular scaffold polyurethane foams.Journal of applied biomaterials & functional materials · 2017Article
- Injectable scaffolds: Preparation and application in dental and craniofacial regeneration.Materials science & engineering. R, Reports : a review journal · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
purposeThe purpose of this work was to investigate the effects of triisocyanate composition on the biological and mechanical properties of biodegradable, injectable polyurethane scaffolds for bone and soft tissue engineering.
methodsScaffolds were synthesized using reactive liquid molding techniques, and were characterized in vivo in a rat subcutaneous model. Porosity, dynamic mechanical properties, degradation rate, and release of growth factors were also measured.
resultsPolyurethane scaffolds were elastomers with tunable damping properties and degradation rates, and they supported cellular infiltration and generation of new tissue. The scaffolds showed a two-stage release profile of platelet-derived growth factor, characterized by a 75% burst release within the first 24 h and slower release thereafter.
conclusionsBiodegradable polyurethanes synthesized from triisocyanates exhibited tunable and superior mechanical properties compared to materials synthesized from lysine diisocyanates. Due to their injectability, biocompatibility, tunable degradation, and potential for release of growth factors, these materials are potentially promising therapies for tissue engineering.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.