Evidence map›Paper›PMID 18516651›Full record

ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2008

Salvage gastrectomy following a combination of biweekly paclitaxel and S-1 for stage IV gastric cancer.

Sumiya Ishigami, Shoji Natsugoe, Akihiro Nakajo, Masataka Matsumoto, Yoshikazu Uenosono, Takaaki Arigami, Tetsuro Setoyama, Hideo Arima, Yasuto Uchikado, Yoshiaki Kita and 2 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 30 citations in OpenAlex.

  1. Conversion therapy for inoperable advanced gastric cancer patients by docetaxel, cisplatin, and S-1 (DCS) chemotherapy: a multi-institutional retrospective study.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2017
    Trial
  2. Trial
  3. Gastrectomy as a secondary surgery for stage IV gastric cancer patients who underwent S-1-based chemotherapy: a multi-institute retrospective study.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2012
    Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Issues on peritoneal metastasis of gastric cancer: an update.World journal of surgical oncology · 2019
    Review
  12. Article
  13. Article
  14. Article
  15. Conversion therapy for gastric cancer: who can make conversion as successful as Goromaru?Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2016
    Article
  16. Article
  17. Treatment of patients with stage IV gastric cancer.Journal of gastrointestinal cancer · 2013
    Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Sumiya IshigamiDigestive Surgery, Surgical Oncology, Kagoshima University School of Medicine, 8-35-1 Sakuragaoka, Kagoshima, 890, Japan. Ishiga@m.kufm.kagoshima-u.ac.jp
Shoji Natsugoe
Akihiro Nakajo
Masataka Matsumoto
Yoshikazu Uenosono
Takaaki Arigami
Tetsuro Setoyama
Hideo Arima
Yasuto Uchikado
Yoshiaki Kita
Ken Sasaki
Takashi Aikou
Kagoshima University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimWe investigated the clinical benefits of salvage gastrectomy for stage IV gastric cancer patients whose distant lesions showed complete response after chemotherapy.

methodsWe enrolled 18 stage IV gastric cancer patients whose distant metastases had disappeared or were controlled by a combination of biweekly paclitaxel (PTX) and S-1. After chemotherapy, these patients received gastrectomy with lymph node dissection. The postoperative outcome was analyzed with respect to both the histological effects of chemotherapy and tumor behavior.

resultsOf the 18 patients, 8 had distant lymph node metastases, 9 had peritoneal dissemination, and five had multiple liver metastases prior to chemotherapy. Fourteen patients received curative surgery (R0). No severe postoperative complications were encountered. Pathological evaluation revealed grade 3 and grade 2 tumor regression in the primary lesion in one and five patients, respectively, and grade 3 and grade 2 tumor regression in the lymph nodes in one and six patients, respectively. Univariate analysis of the patients' prognosis identified R number, gross tumor type, histological grade of tumor regression, and gender as significant factors. Multivariate analysis showed that only the R number was an independent prognostic factor.

conclusionR0 salvage gastrectomy following a combination of biweekly PTX and S-1 may have significant clinical efficacy for advanced gastric cancer patients.

Indexed as

AdultAgedAntimetabolites, AntineoplasticAntineoplastic Agents, PhytogenicDrug Administration ScheduleDrug CombinationsDrug Therapy, CombinationFemaleFollow-Up StudiesGastrectomyHumansMaleMiddle AgedNeoplasm StagingOxonic AcidPaclitaxelAntimetabolites, AntineoplasticAntineoplastic Agents, PhytogenicDrug CombinationsOxonic AcidPaclitaxelS 1 (combination)Tegafur

Identifiers

PMID18516651
OpenAlexW2083863537

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.