ArticleEuropean journal of applied physiology2008
The effect of nitric oxide synthase and cyclooxygenase inhibition on cutaneous microvascular reactivity.
Article in European journal of applied physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 44 citations in OpenAlex.
- Impaired acetylcholine-induced cutaneous vasodilation in young smokers: roles of nitric oxide and prostanoids.American journal of physiology. Heart and circulatory physiology · 2013Trial
- Effects of oral glucose tolerance test on microvascular and autonomic nervous system regulation in young healthy individuals.Scientific reports · 2025Article
- The relationships between acetylcholine-induced chest pain, objective measures of coronary vascular function and symptom status.Frontiers in cardiovascular medicine · 2023Article
- Thermal dysregulation in patients with multiple sclerosis during SARS-CoV-2 infection. The potential therapeutic role of exercise.Multiple sclerosis and related disorders · 2022Review
- Wavelet analysis of laser Doppler microcirculatory signals: Current applications and limitations.Frontiers in physiology · 2022Review
- Acute exhaustive rowing exercise reduces skin microvascular dilator function in young adult rowing athletes.European journal of applied physiology · 2018Article
- Cutaneous blood flow during intradermal NO administration in young and older adults: roles for calcium-activated potassium channels and cyclooxygenase?American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Impaired skin microcirculation in paediatric patients with type 1 diabetes mellitus.Cardiovascular diabetology · 2013Article
- Association of coronary artery calcium score and vascular dysfunction in long-term hemodialysis patients.Hemodialysis international. International Symposium on Home Hemodialysis · 2013Article
- Resting blood flow in the skin: does it exist, and what is the influence of temperature, aging, and diabetes?Journal of diabetes science and technology · 2012Review
- Progesterone enhances adrenergic control of skin blood flow in women with high but not low orthostatic tolerance.The Journal of physiology · 2011Article
- Aerobic training increases skin perfusion by a nitric oxide mechanism in type 2 diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2010Article
- Article
- Vascular pharmacology of epoxyeicosatrienoic acids.Advances in pharmacology (San Diego, Calif.) · 2010Review
- Low fingertip temperature rebound measured by digital thermal monitoring strongly correlates with the presence and extent of coronary artery disease diagnosed by 64-slice multi-detector computed tomography.The international journal of cardiovascular imaging · 2009Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of nitric oxide (NO)- and prostacyclin (PGI(2))-independent mechanism, potentially attributable to endothelium-derived hyperpolarizing factor (EDHF), has not been extensively studied in human skin microcirculation. The aim of our study was to elucidate the contribution of the NO- and PGI(2)-independent mechanism to microvascular reactivity of cutaneous microcirculation. Skin perfusion was measured on the volar aspect of the forearm in 12 healthy male subjects (mean age 25.0 +/- 1.5), using laser Doppler (LD) fluxmetry. Combined endothelial nitric oxide synthase (eNOS) and cyclooxygenase (COX) inhibition was achieved by an intradermal injection (10 microl) of the eNOS inhibitor, L(omega)-monomethyl L-arginine (L-NMMA, 10 mM) and the COX inhibitor, diclofenac (10 mM); saline was injected as a control. LD flux was assessed at rest and after an iontophoretical application of acetylcholine (ACh, 1%), an endothelial agonist and sodium nitroprusside (SNP, 1%), an endothelium-independent agonist, respectively. Combined eNOS and COX inhibition had no effect on the baseline LDF (12.5 +/- 2.3 PU (perfusion units) in control vs. 10.9 +/- 1.8 PU in the treated site). On the other hand, the ACh-stimulated increase in LDF was significantly attenuated after eNOS and COX inhibition (390.5 +/- 43.5%), compared to the control (643.7 +/- 80.3% increase, t-test, P < 0.05). Nevertheless, at least 60% of ACh-mediated vasodilatation was preserved after combined eNOS and COX inhibition. eNOS and COX inhibition had no impact on the SNP-stimulated increase in LDF (768.8 +/- 70.5% in control vs. 733.5 +/- 54.6% in the treated site). These findings indicate that NO- and PGI(2)-independent mechanism plays an important role in the regulation of blood flow in the human skin microcirculation.
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