ArticlePLoS computational biology2008
Astrocytes optimize the synaptic transmission of information.
Article in PLoS computational biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- A 3D-1D-0D multiscale model of the neuro-glial-vascular unit for synaptic and vascular dynamics in the dorsal vagal complex.Journal of mathematical biology · 2025Article
- ASTROGLIA: Molecular Mechanisms, Functional Roles, and Neurophysiological Implications in the Central Nervous System.Life (Basel, Switzerland) · 2025Review
- Flavonoids as Potential Therapeutics Against Neurodegenerative Disorders: Unlocking the Prospects.Neurochemical research · 2024Review
- Amyloid pathology disrupts gliotransmitter release in astrocytes.PLoS computational biology · 2022Article
- Bayesian inference of molecular kinetic parameters from astrocyte calcium imaging data.MethodsX · 2022Article
- Neuron-Glia Interactions and Brain Circuits.Advances in experimental medicine and biology · 2022Article
- Maintenance of postsynaptic neuronal excitability by a positive feedback loop of postsynaptic BDNF expression.Cognitive neurodynamics · 2018Article
- Underlying Mechanisms of Cooperativity, Input Specificity, and Associativity of Long-Term Potentiation Through a Positive Feedback of Local Protein Synthesis.Frontiers in computational neuroscience · 2018Article
- Computational Models for Calcium-Mediated Astrocyte Functions.Frontiers in computational neuroscience · 2018Review
- Article
- Degeneracy in the regulation of short-term plasticity and synaptic filtering by presynaptic mechanisms.The Journal of physiology · 2017Article
- Microcircuits in respiratory rhythm generation: commonalities with other rhythm generating networks and evolutionary perspectives.Current opinion in neurobiology · 2016Review
- Impact of Plant-Derived Flavonoids on Neurodegenerative Diseases.Neurotoxicity research · 2016Review
- Data and model tango to aid the understanding of astrocyte-neuron signaling.Frontiers in computational neuroscience · 2014Article
- Neuron-glia networks: integral gear of brain function.Frontiers in cellular neuroscience · 2014Review
- Neuromodulatory systems.Frontiers in neural circuits · 2013Review
- A mathematical model for astrocytes mediated LTP at single hippocampal synapses.Journal of computational neuroscience · 2012Article
- Review
- A mathematical model of the tripartite synapse: astrocyte-induced synaptic plasticity.Journal of biological physics · 2012Article
- Dependence of spontaneous neuronal firing and depolarisation block on astroglial membrane transport mechanisms.Journal of computational neuroscience · 2012Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chemical synapses transmit information via the release of neurotransmitter-filled vesicles from the presynaptic terminal. Using computational modeling, we predict that the limited availability of neurotransmitter resources in combination with the spontaneous release of vesicles limits the maximum degree of enhancement of synaptic transmission. This gives rise to an optimal tuning that depends on the number of active zones. There is strong experimental evidence that astrocytes that enwrap synapses can modulate the probabilities of vesicle release through bidirectional signaling and hence regulate synaptic transmission. For low-fidelity hippocampal synapses, which typically have only one or two active zones, the predicted optimal values lie close to those determined by experimentally measured astrocytic feedback, suggesting that astrocytes optimize synaptic transmission of information.
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