ReviewPLoS computational biology2008
Why are computational neuroscience and systems biology so separate?
Review in PLoS computational biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed.
- How to Foster Challenging Interdisciplinary Collaborations: Can Philosophy Support Neuroscientists?The European journal of neuroscience · 2026Review
- Generalised Hodgkin-Huxley model captures human P2X and AMPA receptor currents.The Journal of physiology · 2026Article
- Building on models-a perspective for computational neuroscience.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Computational Neuroscience's Influence on Autism Neuro-Transmission Research: Mapping Serotonin, Dopamine, GABA, and Glutamate.Biomedicines · 2025Review
- Differential behaviors of calcium-induced calcium release in one dimensional dendrite by Nernst-Planck equation, cable model and pure diffusion model.Cognitive neurodynamics · 2024Article
- Thinking about the action potential: the nerve signal as a window to the physical principles guiding neuronal excitability.Frontiers in cellular neuroscience · 2023Article
- Connectivity concepts in neuronal network modeling.PLoS computational biology · 2022Review
- Article
- Modernizing the NEURON Simulator for Sustainability, Portability, and Performance.Frontiers in neuroinformatics · 2022Article
- Synaptic Role in Facilitating Synchronous Theta Oscillations in a Hybrid Hippocampal Neuronal Network.Frontiers in computational neuroscience · 2022Article
- Review
- Parameter estimation and identifiability in a neural population model for electro-cortical activity.PLoS computational biology · 2019Article
- Biophysical Psychiatry-How Computational Neuroscience Can Help to Understand the Complex Mechanisms of Mental Disorders.Frontiers in psychiatry · 2019Review
- Poetic Science: Bidirectional Reflection in Science and Medicine.The Permanente journal · 2019Article
- Replicability or reproducibility? On the replication crisis in computational neuroscience and sharing only relevant detail.Journal of computational neuroscience · 2018Article
- Computational Models for Calcium-Mediated Astrocyte Functions.Frontiers in computational neuroscience · 2018Review
- Using NEURON for Reaction-Diffusion Modeling of Extracellular Dynamics.Frontiers in neuroinformatics · 2018Article
- Combined Computational Systems Biology and Computational Neuroscience Approaches Help Develop of Future "Cognitive Developmental Robotics".Frontiers in neurorobotics · 2017Article
- Reproducibility and Comparability of Computational Models for Astrocyte Calcium Excitability.Frontiers in neuroinformatics · 2017Article
- Is realistic neuronal modeling realistic?Journal of neurophysiology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite similar computational approaches, there is surprisingly little interaction between the computational neuroscience and the systems biology research communities. In this review I reconstruct the history of the two disciplines and show that this may explain why they grew up apart. The separation is a pity, as both fields can learn quite a bit from each other. Several examples are given, covering sociological, software technical, and methodological aspects. Systems biology is a better organized community which is very effective at sharing resources, while computational neuroscience has more experience in multiscale modeling and the analysis of information processing by biological systems. Finally, I speculate about how the relationship between the two fields may evolve in the near future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.