Evidence map›Paper›PMID 18515827›Full record

ArticleJournal of experimental botany2008

Identification of auxins by a chemical genomics approach.

May Christian, William B Hannah, Hartwig Lüthen, Alan M Jones

Abstract read
In one paragraph

Article in Journal of experimental botany, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Chemical Biology in Auxin Research.Cold Spring Harbor perspectives in biology · 2021
    Review
  6. Chlorinated Auxins-How DoesInternational journal of molecular sciences · 2020
    Article
  7. Selective auxin agonists induce specific AUX/IAA protein degradation to modulate plant development.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Arabidopsis AIR12 influences root development.Physiology and molecular biology of plants : an international journal of functional plant biology · 2015
    Article
  14. Article
  15. Article
  16. Hormone interactions in stomatal function.Plant molecular biology · 2009
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

May ChristianDepartment of Biology, The University of North Carolina at Chapel Hill, NC 27599-3280, USA.
William B Hannah
Hartwig Lüthen
Alan M Jones

Funding

Novel Mechanisms Regulating the Heterotrimeric G Protein ComplexR01GM065989 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JONES, ALAN M. · 2002 to 2023
$5.5M
NIGMS NIH HHS R01 GM065989NIGMS NIH HHS R01GM065989
6 · The paper itself

Abstract

Thirteen auxenic compounds were discovered in a screen of 10 000 compounds for auxin-like activity in Arabidopsis roots. One of the most potent substances was 2-(4-chloro-2-methylphenoxy)-N-(4-H-1,2,4-triazol-3-yl)acetamide (WH7) which shares similar structure to the known auxenic herbicide 2,4-dichlorophenoxyacetic acid (2,4-D). A selected set of 20 analogues of WH7 was used to provide detailed information about the structure-activity relationship based on their efficacy at inhibiting and stimulating root and shoot growth, respectively, and at induction of gene expression. It was shown that WH7 acts in a genetically defined auxin pathway. These small molecules will extend the arsenal of substances that can be used to define auxin perception site(s) and to dissect subsequent signalling events.

Indexed as

GenomicsArabidopsisArabidopsis ProteinsDrug ResistanceGene Expression Regulation, PlantGlycolatesIndoleacetic AcidsMembrane Transport ProteinsPhenotypePlant Growth RegulatorsPlant RootsSmall Molecule LibrariesStructure-Activity Relationship1-naphthoxyacetic acidArabidopsis ProteinsGlycolatesIndoleacetic AcidsMembrane Transport ProteinsPIN1 protein, ArabidopsisPlant Growth RegulatorsSmall Molecule Libraries2,4-DAuxingrowth controlsensitivitystructure–activity

Identifiers

PMID18515827
PMCPMC2486469

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.