ArticleThe Journal of biological chemistry2008
Physical and functional interactions of monoubiquitylated transactivators with the proteasome.
Article in The Journal of biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- Protein Engineering in the Ubiquitin System: Tools for Discovery and Beyond.Pharmacological reviews · 2020Review
- Proteasome inhibition creates a chromatin landscape favorable to RNA Pol II processivity.The Journal of biological chemistry · 2020Article
- The 19S proteasome regulates subtelomere silencing and facultative heterochromatin formation in fission yeast.Current genetics · 2018Article
- Ubiquitin C-terminal hydrolase37 regulates Tcf7 DNA binding for the activation of Wnt signalling.Scientific reports · 2017Article
- Cullin-RING ubiquitin ligases in salicylic acid-mediated plant immune signaling.Frontiers in plant science · 2015Review
- Review
- The 26S proteasome and initiation of gene transcription.Biomolecules · 2014Review
- Ubiquitin signals proteolysis-independent stripping of transcription factors.Molecular cell · 2014Article
- Article
- Regulation of gene expression by the ubiquitin-proteasome system.Seminars in cell & developmental biology · 2012Review
- Distinct regulatory mechanisms of eukaryotic transcriptional activation by SAGA and TFIID.Biochimica et biophysica acta · 2011Review
- Phosphorylation and ubiquitination of degron proximal residues are essential for class II transactivator (CIITA) transactivation and major histocompatibility class II expression.The Journal of biological chemistry · 2010Article
- No Splicing, no dicing: non-proteolytic roles of the ubiquitin-proteasome system in transcription.The Journal of biological chemistry · 2010Review
- The hydrophobic patch of ubiquitin is required to protect transactivator-promoter complexes from destabilization by the proteasomal ATPases.Nucleic acids research · 2010Article
- Non-proteolytic regulation of p53-mediated transcription through destabilization of the activator.promoter complex by the proteasomal ATPases.The Journal of biological chemistry · 2009Article
- Melanoma antigen gene protein-A11 (MAGE-11) F-box links the androgen receptor NH2-terminal transactivation domain to p160 coactivators.The Journal of biological chemistry · 2009Article
- Ubiquitin-binding domains - from structures to functions.Nature reviews. Molecular cell biology · 2009Review
- S-glutathionylation of the Rpn2 regulatory subunit inhibits 26 S proteasomal function.The Journal of biological chemistry · 2009Article
- Proteasomal degradation of the papillomavirus E2 protein is inhibited by overexpression of bromodomain-containing protein 4.Journal of virology · 2009Article
- Origin and function of ubiquitin-like proteins.Nature · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Destabilization of activator-DNA complexes by the proteasomal ATPases can inhibit transcription by limiting activator interaction with DNA. Modification of the activator by monoubiquitylation protects the activator from this destabilization activity. In this study, we probe the mechanism of this protective effect of monoubiquitylation. Using novel label transfer and chemical cross-linking techniques, we show that ubiquitin contacts the ATPase complex directly, apparently via Rpn1 and Rpt1. This interaction results in the dissociation of the activation domain-ATPase complex via an allosteric process. A model is proposed in which activator monoubiquitylation serves to limit the lifetime of the activator-ATPase complex interaction and thus the ability of the ATPases to unfold the activator and dissociate the protein-DNA complex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.