Trial reportThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2008
Preventing depression in later life: translation from concept to experimental design and implementation.
Trial report in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Effects of Vitamin DThe Journal of clinical psychiatry · 2023Trial
- Treatment of post traumatic stress disorder symptoms in emotionally distressed individuals.Psychiatry research · 2014Trial
- Effects of problem solving therapy on mental health outcomes in family caregivers of persons with a new diagnosis of mild cognitive impairment or early dementia: a randomized controlled trial.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2014Trial
- Subsyndromal depression and anxiety in older adults: health related, functional, cognitive and diagnostic implications.Journal of psychiatric research · 2013Trial
- Use of the late-life function and disability instrument to assess disability in major depression.Journal of the American Geriatrics Society · 2009Trial
- Reimagining Resilience in Aging: Leveraging AI/ML, Big Data Analytics, and Systems Innovation.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2025Article
- The VITamin D and OmegA-3 TriaL-Depression Endpoint Prevention (VITAL-DEP): Rationale and design of a large-scale ancillary study evaluating vitamin D and marine omega-3 fatty acid supplements for prevention of late-life depression.Contemporary clinical trials · 2018Article
- Problem-Solving Therapy in the Elderly.Current treatment options in psychiatry · 2014Article
- Post-traumatic stress disorder symptoms in emotionally distressed individuals referred for a depression prevention intervention: relationship to problem-solving skills.International journal of geriatric psychiatry · 2012Article
- Early intervention to reduce the global health and economic burden of major depression in older adults.Annual review of public health · 2012Review
- Sustained adoption of an evidence-based treatment: a survey of clinicians certified in problem-solving therapy.Depression research and treatment · 2012Article
- Preventing depression in later life: state of the art and science circa 2011.The Psychiatric clinics of North America · 2011Review
- Community-based partnered research: new directions in mental health services research.Ethnicity & disease · 2011Article
- A comparison of the frequencies of risk factors for depression in older black and white participants in a study of indicated prevention.International psychogeriatrics · 2010Article
- Lifestyle-adjusted function: variation beyond BADL and IADL competencies.The Gerontologist · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
objectiveThe authors detail the public health need for depression prevention research and the decisions made in designing an experiment testing problem solving therapy as "indicated" preventive intervention for high-risk older adults with subsyndromal depression. Special attention is given to the recruitment of African Americans because of well-documented inequalities in mental health services and depression treatment outcomes between races.
methodsA total of 306 subjects (half white, half African American) with scores of 16 or higher on the Center for Epidemiological Studies of Depression Scale, but with no history of major depressive disorder in the past 12 months, are being recruited and randomly assigned to either problem solving therapy-primary care or to a dietary education control condition. Time to, and rate of, incident episodes of major depressive disorder are to be modeled using survival analysis. Level of depressive symptoms will be analyzed via a mixed models approach.
resultsTwenty-two subjects have been recruited into the study, and to date eight have completed the randomly assigned intervention and postintervention assessment. Four of 22 have exited after developing major depressive episodes. None have complained about study procedures or demands. Implementation in a variety of community settings is going well.
conclusionThe data collected to date support the feasibility of translating from epidemiology to RCT design and implementation of empirical depression prevention research in later life.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.