ArticleThe Journal of endocrinology2008
MafA is a dedicated activator of the insulin gene in vivo.
Article in The Journal of endocrinology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The trial behind it
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Who cites it
29 citing papers in PubMed, 50 citations in OpenAlex.
- CaBiomedicines · 2023Review
- Second MAFA Variant Causing a Phosphorylation Defect in the Transactivation Domain and Familial Insulinomatosis.Cancers · 2022Article
- MafA Regulation in β-Cells: From Transcriptional to Post-Translational Mechanisms.Biomolecules · 2022Review
- The Calcium Channel Subunit Gamma-4 as a Novel Regulator of MafA in Pancreatic Beta-Cell Controls Glucose Homeostasis.Biomedicines · 2022Article
- Sex-biased islet β cell dysfunction is caused by the MODY MAFA S64F variant by inducing premature aging and senescence in males.Cell reports · 2021Article
- Identification and integrated analysis of differentially expressed long non-coding RNAs associated with periodontitis in humans.Journal of periodontal research · 2021Article
- Pericytes contribute to the islet basement membranes to promote beta-cell gene expression.Scientific reports · 2021Article
- Examining How the MAFB Transcription Factor Affects Islet β-Cell Function Postnatally.Diabetes · 2019Article
- Cooperative function of Pdx1 and Oc1 in multipotent pancreatic progenitors impacts postnatal islet maturation and adaptability.American journal of physiology. Endocrinology and metabolism · 2018Article
- Systematic single-cell analysis provides new insights into heterogeneity and plasticity of the pancreas.Molecular metabolism · 2017Review
- The MAFB transcription factor impacts islet α-cell function in rodents and represents a unique signature of primate islet β-cells.American journal of physiology. Endocrinology and metabolism · 2016Article
- Inhibition of human insulin gene transcription and MafA transcriptional activity by the dual leucine zipper kinase.Cellular signalling · 2014Article
- Article
- Cdc42/N-WASP signaling links actin dynamics to pancreatic β cell delamination and differentiation.Development (Cambridge, England) · 2014Article
- Generation of insulin-producing cells from the mouse liver using β cell-related gene transfer including Mafa and Mafb.PloS one · 2014Article
- Gene regulatory networks governing pancreas development.Developmental cell · 2013Review
- Leveling Waddington: the emergence of direct programming and the loss of cell fate hierarchies.Nature reviews. Molecular cell biology · 2013Review
- Rosiglitazone promotes PPARγ-dependent and -independent alterations in gene expression in mouse islets.Endocrinology · 2012Article
- Direct lineage conversions: unnatural but useful?Nature biotechnology · 2011Review
- MafA and MafB activity in pancreatic β cells.Trends in endocrinology and metabolism: TEM · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
As successful generation of insulin-producing cells could be used for diabetes treatment, a concerted effort is being made to understand the molecular programs underlying islet beta-cell formation and function. The closely related MafA and MafB transcription factors are both key mammalian beta-cell regulators. MafA and MafB are co-expressed in insulin+beta-cells during embryogenesis, while in the adult pancreas only MafA is produced in beta-cells and MafB in glucagon+alpha-cells. MafB-/- animals are also deficient in insulin+ and glucagon+ cell production during embryogenesis. However, only MafA over-expression selectively induced endogenous Insulin mRNA production in cell line-based assays, while MafB specifically promoted Glucagon expression. Here, we analyzed whether these factors were sufficient to induce insulin+ and/or glucagon+ cell formation within embryonic endoderm using the chick in ovo electroporation assay. Ectopic expression of MafA, but not MafB, promoted Insulin production; however, neither MafA nor MafB were capable of inducing Glucagon. Co-electroporation of MafA with the Ngn3 transcription factor resulted in the development of more organized cell clusters containing both insulin- and glucagon-producing cells. Analysis of chimeric proteins of MafA and MafB demonstrated that chick Insulin activation depended on sequences within the MafA C-terminal DNA-binding domain. MafA was also bound to Insulin and Glucagon transcriptional control sequences in mouse embryonic pancreas and beta-cell lines. Collectively, these results demonstrate a unique ability for MafA to independently activate Insulin transcription.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.