ArticleProceedings of the National Academy of Sciences of the United States of America2008
A nonneural epithelial domain of embryonic cranial neural folds gives rise to ectomesenchyme.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Ectomesenchyme contributes to epidermal stem cell formation through mesenchymal-to-epithelial transition.Nature communications · 2026Article
- Co-option and innovation in neural crest evolution.Science advances · 2026Review
- Fibroblasts fluctuating between mesenchyme and epithelium are involved in hair follicle mesenchyme development.Biochemistry and biophysics reports · 2025Article
- Reassessing the embryonic origin and potential of craniofacial ectomesenchyme.Seminars in cell & developmental biology · 2023Review
- On the road again: Establishment and maintenance of stemness in the neural crest from embryo to adulthood.Stem cells (Dayton, Ohio) · 2021Review
- From head to tail: regionalization of the neural crest.Development (Cambridge, England) · 2020Review
- Insights into the Etiology of Mammalian Neural Tube Closure Defects from Developmental, Genetic and Evolutionary Studies.Journal of developmental biology · 2018Review
- Cre-driver lines used for genetic fate mapping of neural crest cells in the mouse: An overview.Genesis (New York, N.Y. : 2000) · 2018Review
- Should I stay or should I go? Cadherin function and regulation in the neural crest.Genesis (New York, N.Y. : 2000) · 2017Review
- On the Origin of Cells and Derivation of Thyroid Cancer: C Cell Story Revisited.European thyroid journal · 2016Review
- Phenotypic chemical screening using a zebrafish neural crest EMT reporter identifies retinoic acid as an inhibitor of epithelial morphogenesis.Disease models & mechanisms · 2016Article
- Sox10ER(T2) CreER(T2) mice enable tracing of distinct neural crest cell populations.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Article
- Mesodermal origin of median fin mesenchyme and tail muscle in amphibian larvae.Scientific reports · 2015Article
- Cell delamination in the mesencephalic neural fold and its implication for the origin of ectomesenchyme.Development (Cambridge, England) · 2013Article
- How to form and close the brain: insight into the mechanism of cranial neural tube closure in mammals.Cellular and molecular life sciences : CMLS · 2013Review
- An exclusively mesodermal origin of fin mesenchyme demonstrates that zebrafish trunk neural crest does not generate ectomesenchyme.Development (Cambridge, England) · 2013Article
- The hypoxia factor Hif-1α controls neural crest chemotaxis and epithelial to mesenchymal transition.The Journal of cell biology · 2013Article
- Neural crest and olfactory system: new prospective.Molecular neurobiology · 2012Review
- An essential role of variant histone H3.3 for ectomesenchyme potential of the cranial neural crest.PLoS genetics · 2012Article
- Diversity in the molecular and cellular strategies of epithelium-to-mesenchyme transitions: Insights from the neural crest.Cell adhesion & migrationArticle
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neural crest is generally believed to be the embryonic source of skeletogenic mesenchyme (ectomesenchyme) in the vertebrate head and other derivatives, including pigment cells and neurons and glia of the peripheral nervous system. Although classical transplantation experiments leading to this conclusion assumed that embryonic neural folds were homogeneous epithelia, we reported that embryonic cranial neural folds contain spatially and phenotypically distinct domains, including a lateral nonneural domain with cells that coexpress E-cadherin and PDGFRalpha and a thickened mediodorsal neuroepithelial domain where these proteins are reduced or absent. We now show that Wnt1-Cre is expressed in the lateral nonneural epithelium of rostral neural folds and that cells coexpressing Cre-recombinase and PDGFRalpha delaminate precociously from some of this nonneural epithelium. We also show that ectomesenchymal cells exhibit beta-galactosidase activity in embryos heterozygous for an Ecad-lacZ reporter knock- in allele. We conclude that a lateral nonneural domain of the neural fold epithelium, which we call "metablast," is a source of ectomesenchyme distinct from the neural crest. We suggest that closer analysis of the origin of ectomesenchyme might help to understand (i) the molecular-genetic regulation of development of both neural crest and ectomesenchyme lineages; (ii) the early developmental origin of skeletogenic and connective tissue mesenchyme in the vertebrate head; and (iii) the presumed origin of head and branchial arch skeletal and connective tissue structures during vertebrate evolution.
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