ArticleJournal of bacteriology2008
The role of prophage for genome diversification within a clonal lineage of Lactobacillus johnsonii: characterization of the defective prophage LJ771.
Article in Journal of bacteriology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Understanding the probiotic potential of a healthy human vaginal flora, Lactobacillus gasseri K9: genomic and in vitro aspects.Journal, genetic engineering & biotechnology · 2026Article
- RAP44 phage integrase-guided 50K genomic island integration inFrontiers in veterinary science · 2022Article
- The Human Gut Phageome: Origins and Roles in the Human Gut Microbiome.Frontiers in cellular and infection microbiology · 2021Review
- Prophages in Lactobacillus reuteri Are Associated with Fitness Trade-Offs but Can Increase Competitiveness in the Gut Ecosystem.Applied and environmental microbiology · 2019Article
- phiD12-Like Livestock-Associated Prophages Are Associated With Novel Subpopulations ofFrontiers in cellular and infection microbiology · 2019Article
- Deconjugated Bile Salts Produced by Extracellular Bile-Salt Hydrolase-Like Activities from the ProbioticFrontiers in microbiology · 2016Article
- Spontaneously induced prophages in Lactobacillus gasseri contribute to horizontal gene transfer.Applied and environmental microbiology · 2014Article
- Linkage, mobility, and selfishness in the MazF family of bacterial toxins: a snapshot of bacterial evolution.Genome biology and evolution · 2013Article
- Genomic analysis by deep sequencing of the probiotic Lactobacillus brevis KB290 harboring nine plasmids reveals genomic stability.PloS one · 2013Article
- Global expression profile of biofilm resistance to antimicrobial compounds in the plant-pathogenic bacterium Xylella fastidiosa reveals evidence of persister cells.Journal of bacteriology · 2012Article
- Group-specific comparison of four lactobacilli isolated from human sources using differential blast analysis.Genes & nutrition · 2011Article
- Host specific diversity in Lactobacillus johnsonii as evidenced by a major chromosomal inversion and phage resistance mechanisms.PloS one · 2011Article
- Alternative sigma factor sigmaH modulates prophage integration and excision in Staphylococcus aureus.PLoS pathogens · 2010Article
- The not so universal tree of life or the place of viruses in the living world.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2009Article
- Comparative genomic analysis of ten Streptococcus pneumoniae temperate bacteriophages.Journal of bacteriology · 2009Article
- Movers and shakers: influence of bacteriophages in shaping the mammalian gut microbiota.Gut microbesReview
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two independent isolates of the gut commensal Lactobacillus johnsonii were sequenced. These isolates belonged to the same clonal lineage and differed mainly by a 40.8-kb prophage, LJ771, belonging to the Sfi11 phage lineage. LJ771 shares close DNA sequence identity with Lactobacillus gasseri prophages. LJ771 coexists as an integrated prophage and excised circular phage DNA, but phage DNA packaged into extracellular phage particles was not detected. Between the phage lysin gene and attR a likely mazE ("antitoxin")/pemK ("toxin") gene cassette was detected in LJ771 but not in the L. gasseri prophages. Expressed pemK could be cloned in Escherichia coli only together with the mazE gene. LJ771 was shown to be highly stable and could be cured only by coexpression of mazE from a plasmid. The prophage was integrated into the methionine sulfoxide reductase gene (msrA) and complemented the 5' end of this gene, creating a protein with a slightly altered N-terminal sequence. The two L. johnsonii strains had identical in vitro growth and in vivo gut persistence phenotypes. Also, in an isogenic background, the presence of the prophage resulted in no growth disadvantage.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.