ArticleJournal of bacteriology2008
A plasmid-borne Shewanella algae Gene, qnrA3, and its possible transfer in vivo between Kluyvera ascorbata and Klebsiella pneumoniae.
Article in Journal of bacteriology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- Investigation of multidrug-resistant plasmids from carbapenemase-producingFrontiers in microbiology · 2023Article
- Resistome, Mobilome and Virulome Analysis ofMicroorganisms · 2020Article
- Transferable Mechanisms of Quinolone Resistance from 1998 Onward.Clinical microbiology reviews · 2019Review
- Article
- Identification of 76 novel B1 metallo-β-lactamases through large-scale screening of genomic and metagenomic data.Microbiome · 2017Article
- Mechanisms of drug resistance: quinolone resistance.Annals of the New York Academy of Sciences · 2015Review
- Plasmid-mediated quinolone resistance.Microbiology spectrum · 2014Review
- Mobile insertion cassette elements found in small non-transmissible plasmids in Proteeae may explain qnrD mobilization.PloS one · 2014Article
- Coastal seawater bacteria harbor a large reservoir of plasmid-mediated quinolone resistance determinants in Jiaozhou Bay, China.Microbial ecology · 2012Article
- Global fluoroquinolone resistance epidemiology and implictions for clinical use.Interdisciplinary perspectives on infectious diseases · 2012Article
- Description of a 2,683-base-pair plasmid containing qnrD in two Providencia rettgeri isolates.Antimicrobial agents and chemotherapy · 2012Article
- Shewanella infection of snake bites: a twelve-year retrospective study.Clinics (Sao Paulo, Brazil) · 2012Article
- Article
- Plasmid-mediated quinolone resistance: a multifaceted threat.Clinical microbiology reviews · 2009Review
- Resistance plasmid families in Enterobacteriaceae.Antimicrobial agents and chemotherapy · 2009Review
- New plasmid-mediated quinolone resistance gene, qnrC, found in a clinical isolate of Proteus mirabilis.Antimicrobial agents and chemotherapy · 2009Article
- Horizontal gene transfer: sustaining pathogenicity and optimizing host-pathogen interactions.Molecular plant pathology · 2009Review
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The plasmid-borne quinolone resistance gene qnrA1 is prevalent in multidrug-resistant Enterobacteriaceae. A chromosomally encoded homologue in Shewanella algae, qnrA3, has been described. We isolated two qnrA3-positive strains, one of Klebsiella pneumoniae (He96) and one of Kluyvera ascorbata (Kas96), from the feces of an immunocompromised outpatient. The qnrA3 allele was identical to that of S. algae except for 5 nucleotides and differed from qnrA1 by 29 nucleotides affecting three amino acids. The analysis of the qnrA3 genetic environment showed that qnrA3 was inserted downstream from an ISCR1 element at a recombination crossover site described for other resistance genes, including qnrA1, and immediately upstream from IS26, a situation not described before. IS26 preceded an incomplete class 1 integron which contained, among other genes, aac(6')-Ib-cr, another transferable quinolone resistance gene, and the beta-lactamase gene bla(OXA-1/30). The 10-kb fragment encompassing qnrA3 was compared to previously described qnrA1-containing plasmids and multidrug-resistant plasmids; it shares identical sequences with pC15a, pHSH2, pQR1, pQKp311H, and pSAL-1 but with rearrangements, deletions, and mutations. Conjugal transfer of qnrA3 was highly efficient (10(-2)) from K. pneumoniae He96 or K. ascorbata Kas96 to Escherichia coli J53 but less so (10(-5)) from either donor to a clinical strain of Enterobacter cloacae. This first description of a plasmid-borne copy and of the in vitro transfer of qnrA3 is taken to illustrate its likely in vivo transfer from S. algae to the Enterobacteriaceae.
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