ArticleBiophysical journal2008
Examining the contributions of lipid shape and headgroup charge on bilayer behavior.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed, 153 citations in OpenAlex.
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- Coordination of transporter, cargo, and membrane properties during non-vesicular lipid transport.Communications biology · 2024Article
- Peptide-Membrane Docking and Molecular Dynamic Simulation of In Silico Detected Antimicrobial Peptides from Portulaca oleracea's Transcriptome.Probiotics and antimicrobial proteins · 2024Article
- Differential interactions of essential and toxic metal ions with biologically relevant phosphatidic acid and phosphatidylserine membranes.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024Article
- Binding equations for the lipid composition dependence of peripheral membrane-binding proteins.Biophysical journal · 2024Article
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- Peptide Flexibility and the Hydrophobic Moment are Determinants to Evaluate the Clinical Potential of Magainins.The Journal of membrane biology · 2023Article
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- Lipid Corona Formation on Micro- and Nanoplastic Particles Modulates Uptake and Toxicity in A549 Cells.Materials (Basel, Switzerland) · 2023Article
- Lipid peroxidation in diamond supported bilayers.Nanoscale · 2023Article
- Molecular Dynamics Simulation of Antimicrobial Peptide CM15 inIranian journal of biotechnology · 2023Article
- Lipid Structure Determines the Differential Impact of Single Metal Additions and Binary Mixtures of Manganese, Calcium and Magnesium on Membrane Fluidity and Liposome Size.International journal of molecular sciences · 2023Article
- Modulation of Anionic Lipid Bilayers by Specific Interplay of Protons and Calcium Ions.Biomolecules · 2022Article
- Particle-based model of mechanosensory contractility kit assembly.Biophysical journal · 2022Article
- Single-Molecule Trapping and Measurement in a Nanostructured Lipid Bilayer System.Langmuir : the ACS journal of surfaces and colloids · 2022Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
To better understand bilayer property dependency on lipid electrostatics and headgroup size, we use atomistic molecular dynamics simulations to study negatively charged and neutral lipid membranes. We compare the negatively charged phosphatidic acid (PA), which at physiological pH and salt concentration has a negative spontaneous curvature, with the negatively charged phosphatidylglycerol (PG) and neutrally charged phosphatidylcholine (PC), both of which have zero spontaneous curvature. The PA lipids are simulated using two different sets of partial charges for the headgroup and the varied charge distribution between the two PA systems results in significantly different locations for the Na(+) ions relative to the water/membrane interface. For one PA system, the Na(+) ions are localized around the phosphate group. In the second PA system, the Na(+) ions are located near the ester carbonyl atoms, which coincides with the preferred location site for the PG Na(+) ions. We find that the Na(+) ion location has a larger effect on bilayer fluidity properties than lipid headgroup size, where the A(lipid) and acyl chain order parameter values are more similar between the PA and PG bilayers that have Na(+) ions located near the ester groups than between the two PA bilayers.
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