ArticleBiophysical journal2008
Two characteristic regimes in frequency-dependent dynamic reorientation of fibroblasts on cyclically stretched substrates.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
90 citing papers in PubMed.
- Effects of a skin-massaging device on the ex-vivo expression of human dermis proteins and in-vivo facial wrinkles.PloS one · 2017Trial
- Restoration of structural organization in engineered cardiac microtissues is promoted by cardiomyocyte beating.Communications biology · 2026Article
- Cyclic stretch induces autophagy-mediated focal adhesion remodeling and activates mitochondria.Life science alliance · 2026Article
- Article
- Extracellular osmolarity regulates osteoblast migration through the TRPV4-Rho/ROCK signaling.Communications biology · 2025Article
- Structural response of microtubule and actin cytoskeletons to direct intracellular load.The Journal of cell biology · 2025Article
- A Microfluidic-Based Cell-Stretching Culture Device That Allows for Easy Preparation of Slides for Observation with High-Magnification Objective Lenses.Micromachines · 2025Article
- Impact of uniaxial cyclic stretching on matrix-associated endothelial cell responses.Materials today. Bio · 2024Article
- Effects of high-frequency mechanical stimuli on flow related vascular cell biology.The International journal of artificial organs · 2024Review
- Can repetitive mechanical motion cause structural damage to axons?Frontiers in molecular neuroscience · 2024Review
- Article
- Cyclic stretching combined with cell-cell adhesion is sufficient for inducing cell intercalation.Biophysical journal · 2023Article
- Cyclic stretch-regulated wound healing.Biophysical journal · 2023Article
- A Statistical Mechanics Approach to Describe Cell Reorientation Under Stretch.Bulletin of mathematical biology · 2023Article
- Characteristic energy scales of active fluctuations in adherent cells.Biophysical reports · 2023Review
- Cell reorientation on a cyclically strained substrate.PNAS nexus · 2022Article
- Design and aligner-assisted fast fabrication of a microfluidic platform for quasi-3D cell studies on an elastic polymer.Bioactive materials · 2022Article
- Mechanomodulation: Physical Treatment Modalities Employ Mechanotransduction to Improve Scarring.European burn journal · 2022Article
- A mechanistic motor-clutch model that explains cell shape dynamics to cyclic stretch.Molecular biology of the cell · 2022Article
- Cellular mechanics of wound formation in single cell layer under cyclic stretching.Biophysical journal · 2022Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cells adherent on a cyclically stretched substrate with a periodically varying uniaxial strain are known to dynamically reorient nearly perpendicular to the strain direction. We investigate the dynamic reorientation of rat embryonic and human fibroblast cells over a range of stretching frequency from 0.0001 to 20 s(-1) and strain amplitude from 1% to 15%. We report quantitative measurements that show that the mean cell orientation changes exponentially with a frequency-dependent characteristic time from 1 to 5 h. At subconfluent cell densities, this characteristic time for reorientation shows two characteristic regimes as a function of frequency. For frequencies below 1 s(-1), the characteristic time decreases with a power law as the frequency increases. For frequencies above 1 s(-1), it saturates at a constant value. In addition, a minimum threshold frequency is found below that no significant cell reorientation occurs. Our results are consistent for the two different fibroblast types and indicate a saturation of molecular mechanisms of mechanotransduction or response machinery for subconfluent cells within the frequency regime under investigation. For confluent cell layers, we observe similar behaviors of reorientation under cyclic stretch but no saturation in the characteristic time with frequency, suggesting that cell-cell contacts can play an important role in the response machinery of cells under mechanical strain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.