ArticleBiophysical journal2008
The effects of reversibility and noise on stochastic phosphorylation cycles and cascades.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Pools of Independently Cycling Inositol Phosphates Revealed by Pulse Labeling withJournal of the American Chemical Society · 2025Article
- A system-level model reveals that transcriptional stochasticity is required for hematopoietic stem cell differentiation.NPJ systems biology and applications · 2024Article
- Threshold response and bistability in gene regulation by small noncoding RNA.The European physical journal. E, Soft matter · 2018Article
- Exploring the mechanisms of differentiation, dedifferentiation, reprogramming and transdifferentiation.PloS one · 2014Article
- Multi-scale modeling in biology: how to bridge the gaps between scales?Progress in biophysics and molecular biology · 2011Review
- Emergence of switch-like behavior in a large family of simple biochemical networks.PLoS computational biology · 2011Article
- Bimodal gene expression in noncooperative regulatory systems.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Temperature control of fimbriation circuit switch in uropathogenic Escherichia coli: quantitative analysis via automated model abstraction.PLoS computational biology · 2010Article
- Introducing total substrates simplifies theoretical analysis at non-negligible enzyme concentrations: pseudo first-order kinetics and the loss of zero-order ultrasensitivity.Journal of mathematical biology · 2010Article
- Stochastic bistability and bifurcation in a mesoscopic signaling system with autocatalytic kinase.Biophysical journal · 2010Article
- Stochastic bimodalities in deterministically monostable reversible chemical networks due to network topology reduction.The Journal of chemical physics · 2009Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The phosphorylation-dephosphorylation cycle is a common motif in cellular signaling networks. Previous work has revealed that, when driven by a noisy input signal, these cycles may exhibit bistable behavior. Here, a recently introduced theorem on network bistability is applied to prove that the existence of bistability is dependent on the stochastic nature of the system. Furthermore, the thermodynamics of simple cycles and cascades is investigated in the stochastic setting. Because these cycles are driven by the ATP hydrolysis potential, they may operate far from equilibrium. It is shown that sufficient high ATP hydrolysis potential is necessary for the existence of a bistable steady state. For the single-cycle system, the ensemble average behavior follows the ultrasensitive response expected from analysis of the corresponding deterministic system, but with significant fluctuations. For the two-cycle cascade, the average behavior begins to deviate from the expected response of the deterministic system. Examination of a two-cycle cascade reveals that the bistable steady state may be either propagated or abolished along a cascade, depending on the parameters chosen. Likewise, the variance in the response can be maximized or minimized by tuning the number of enzymes in the second cycle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.